» Articles » PMID: 31811730

The Dentate Gyrus in Depression

Overview
Journal Eur J Neurosci
Specialty Neurology
Date 2019 Dec 8
PMID 31811730
Citations 12
Authors
Affiliations
Soon will be listed here.
Abstract

Extensive preclinical research has been conducted in recent years to reveal the cell types, neuronal circuits and molecular and morphological changes implicated in the function of the dentate gyrus in depression. This was profoundly facilitated by the emergence of methods such as gene targeting, neuronal cell activity manipulation, including optogenetics and chemogenetics, and the development of novel RNA sequencing technology and powerful MRI imagers that were used in clinical studies. These advancements provided researchers with the precise skills needed to evaluate the changes in the dentate gyrus structure and cell function in rodent models as well as in brains of depressed and medicated patients. Here, we review these latest findings and discuss the existing gaps in our knowledge of the role of the dentate gyrus in depression and in mediating the response to antidepressant therapies.

Citing Articles

Semaglutide Attenuates Anxious and Depressive-Like Behaviors and Reverses the Cognitive Impairment in a Type 2 Diabetes Mellitus Mouse Model Via the Microbiota-Gut-Brain Axis.

de Paiva I, da Silva R, Mendonca I, de Souza J, Peixoto C J Neuroimmune Pharmacol. 2024; 19(1):36.

PMID: 39042202 DOI: 10.1007/s11481-024-10142-w.


Haloperidol, Olanzapine, and Risperidone Induce Morphological Changes in an In Vitro Model of Human Hippocampal Neurogenesis.

Jezso B, Kalman S, Farkas K, Hathy E, Vincze K, Kovacs-Schoblocher D Biomolecules. 2024; 14(6).

PMID: 38927091 PMC: 11201986. DOI: 10.3390/biom14060688.


Adiponectin rescues synaptic plasticity in the dentate gyrus of a mouse model of Fragile X Syndrome.

Thacker J, Bettio L, Liang S, Shkolnikov I, Collingridge G, Christie B Philos Trans R Soc Lond B Biol Sci. 2024; 379(1906):20230221.

PMID: 38853554 PMC: 11343265. DOI: 10.1098/rstb.2023.0221.


Influenza A Virus PB1-F2 Induces Affective Disorder by Interfering Synaptic Plasticity in Hippocampal Dentate Gyrus.

Wang S, Zhang H, Liu R, Han P, Yang Q, Cheng C Mol Neurobiol. 2024; 61(10):8293-8306.

PMID: 38488981 DOI: 10.1007/s12035-024-04107-6.


Role of Hippocampal miR-132-3p in Modifying the Function of Protein Phosphatase Mg2+/Mn2+-dependent 1 F in Depression.

Ma X, Li Q, Chen G, Xie J, Wu M, Meng F Neurochem Res. 2023; 48(8):2514-2530.

PMID: 37036545 DOI: 10.1007/s11064-023-03926-8.