Pentafluorophenyl Platinum(II) Complexes of PTA and Its N-Allyl and N-Benzyl Derivatives: Synthesis, Characterization and Biological Activity

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2019 Nov 30

PMID 31779206

Citations 3

Authors

Paolo Sgarbossa

Urszula Sliwinska-Hill

M Fatima C Guedes da Ilva

Barbara Bazanow

Aleksandra Pawlak

Natalia Jackulak

Dominik Poradowski

Armando J L Pombeiro

Piotr Smolenski

Affiliations

Soon will be listed here.

Abstract

From the well-known 1,3,5-triaza-phosphaadamantane (PTA, ), the novel N-allyl and N-benzyl tetrafuoroborate salts 1-allyl-1-azonia-3,5-diaza-7-phosphaadamantane (APTA(BF), ) and 1-benzyl-1-azonia-3,5-diaza-7-phosphaadamantane (BzPTA(BF), ) were obtained. These phosphines were then allowed to react with (Pt(μ-Cl)(CF)(tht)) (tht = tetrahydrothiophene) affording the water soluble Pt(II) complexes (PtCl(CF)(PTA)) () and its bis-cationic congeners (PtCl(CF)(APTA))(BF) () and (PtCl(CF)(BzPTA))(BF) (). The compounds were fully characterized by multinuclear NMR, ESI-MS, elemental analysis and (for ) also by single crystal X-ray diffraction, which proved the configuration of the phosphine ligands. Furthermore, in order to evaluate the cytotoxic activities of all complexes the normal human dermal fibroblast (NHDF) cell culture were used. The antineoplastic activity of the investigated compounds was checked against the human lung carcinoma (A549), epithelioid cervix carcinoma (HeLa) and breast adenocarcinoma (MCF-7) cell cultures. Interactions between the complexes and human serum albumin (HSA) using fluorescence spectroscopy and circular dichroism spectroscopy (CD) were also investigated.

Citing Articles

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Self-Assembly and Multifaceted Bioactivity of a Silver(I) Quinolinate Coordination Polymer.

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