Evolution of Placental Invasion and Cancer Metastasis Are Causally Linked

Overview

Journal Nat Ecol Evol

Publisher Springer Nature

Specialty Biology

Date 2019 Nov 27

PMID 31768023

Citations 40

Authors

Kshitiz

Junaid Afzal

Jamie D Maziarz

Archer Hamidzadeh

Cong Liang

Eric M Erkenbrack

Hong Nam Kim

Jan-Dirk Haeger

Christiane Pfarrer

Thomas Hoang

Troy Ott

Thomas Spencer

Mihaela Pavlicev

Douglas F Antczak

Andre Levchenko

Gunter P Wagner

Affiliations

Soon will be listed here.

Abstract

Among mammals, placental invasion is correlated with vulnerability to malignancy. Animals with more invasive placentation (for example, humans) are more vulnerable to malignancy. To explain this correlation, we propose the hypothesis of 'Evolved Levels of Invasibility' proposing that the evolution of invasibility of stromal tissue affects both placental and cancer invasion. We provide evidence for this using an in vitro model. We find that bovine endometrial and skin fibroblasts are more resistant to invasion than are their human counterparts. Gene expression profiling identified genes with high expression in human but not in bovine fibroblasts. Knocking down a subset of them in human fibroblasts leads to stronger resistance to cancer cell invasion. Identifying the evolutionary determinants of stromal invasibility can provide important insights to develop rational antimetastatic therapeutics.

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