Sex-dependent Dominance Maintains Migration Supergene in Rainbow Trout

Overview

Journal Nat Ecol Evol

Publisher Springer Nature

Specialty Biology

Date 2019 Nov 27

PMID 31768021

Citations 111

Authors

Devon E Pearse

Nicola J Barson

Torfinn Nome

Guangtu Gao

Matthew A Campbell

Alicia Abadia-Cardoso

Eric C Anderson

David E Rundio

Thomas H Williams

Kerry A Naish

Thomas Moen

Sixin Liu

Matthew Kent

Michel Moser

David R Minkley

Eric B Rondeau

Marine S O Brieuc

Simen Rod Sandve

Michael R Miller

Lucydalila Cedillo

Kobi Baruch

Alvaro G Hernandez

Gil Ben-Zvi

Doron Shem-Tov

Omer Barad

Kirill Kuzishchin

John Carlos Garza

Steven T Lindley

Ben F Koop

Gary H Thorgaard

Yniv Palti

Sigbjorn Lien

Affiliations

Soon will be listed here.

Abstract

Males and females often differ in their fitness optima for shared traits that have a shared genetic basis, leading to sexual conflict. Morphologically differentiated sex chromosomes can resolve this conflict and protect sexually antagonistic variation, but they accumulate deleterious mutations. However, how sexual conflict is resolved in species that lack differentiated sex chromosomes is largely unknown. Here we present a chromosome-anchored genome assembly for rainbow trout (Oncorhynchus mykiss) and characterize a 55-Mb double-inversion supergene that mediates sex-specific migratory tendency through sex-dependent dominance reversal, an alternative mechanism for resolving sexual conflict. The double inversion contains key photosensory, circadian rhythm, adiposity and sex-related genes and displays a latitudinal frequency cline, indicating environmentally dependent selection. Our results show sex-dependent dominance reversal across a large autosomal supergene, a mechanism for sexual conflict resolution capable of protecting sexually antagonistic variation while avoiding the homozygous lethality and deleterious mutations associated with typical heteromorphic sex chromosomes.

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