Antiviral Activity of Flavonoids Present in Aerial Parts of Against Hepatitis B Virus, Poliovirus, and Herpes Simplex Virus

Overview

Journal EXCLI J

Specialty Biology

Date 2019 Nov 26

PMID 31762727

Citations 19

Authors

Joseph Thomas Ortega

Maria Luisa Serrano

Alirica Isabel Suarez

Jani Baptista

Flor Helene Pujol

Lucia Vicenta Cavallaro

Hector Rodolfo Campos

Hector Rafael Rangel

Affiliations

Soon will be listed here.

Abstract

is a neotropical plant present in South America and it has been evaluated in several biological models due to the presence of active metabolites. Nevertheless, there is a limited quantity of studies related to the antiviral activity of the compounds present in this . In our work, the antiviral effect of the compounds isolated from the aerial parts of was evaluated against Hepatitis B virus (HBV), Herpes Simplex Virus type 1 (HSV-1), and Poliovirus type 1 (PV-1). The cytopathic effect and viral quantification by qPCR were determined as indicative of antiviral activity. Our data show that myricetin rhamnoside (MyrG), myricetin-3-α-O-ramnosil (1→6)-α-galactoside (MyrGG), 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone (PMF), 5-hydroxy-3,6,7,3',4'pentamethoxyflavone (PMF-OH) had antiviral activity without cytotoxic effects. The methoxyflavones PMF and PMF-OH were the most active compounds, showing an antiviral effect against all the evaluated viruses. Computational studies showed that these compounds could interact with the Reverse Transcriptase. Altogether, these results suggest that the flavonoids (related to myricetin and methoxyflavones) are the main antiviral compounds present in the aerial parts of . Furthermore, our results showed that the methoxyflavones have a broad antiviral activity, which represents an opportunity to evaluate these flavonoids as lead molecules to develop new antiviral compounds.

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