Transcription Factor Znf2 Coordinates with the Chromatin Remodeling SWI/SNF Complex to Regulate Cryptococcal Cellular Differentiation

Overview

Journal Commun Biol

Specialty Biology

Date 2019 Nov 23

PMID 31754642

Citations 18

Authors

Jianfeng Lin

Youbao Zhao

Aileen R Ferraro

Ence Yang

Zachary A Lewis

Xiaorong Lin

Affiliations

Soon will be listed here.

Abstract

Cellular differentiation is instructed by developmental regulators in coordination with chromatin remodeling complexes. Much information about their coordination comes from studies in the model ascomycetous yeasts. It is not clear, however, what kind of information that can be extrapolated to species of other phyla in Kingdom Fungi. In the basidiomycete , the transcription factor Znf2 controls yeast-to-hypha differentiation. Through a forward genetic screen, we identified the basidiomycete-specific factor Brf1. We discovered Brf1 works together with Snf5 in the SWI/SNF chromatin remodeling complex in concert with existent Znf2 to execute cellular differentiation. We demonstrated that SWI/SNF assists Znf2 in opening the promoter regions of hyphal specific genes, including the gene itself. This complex also supports Znf2 to fully associate with its target regions. Importantly, our findings revealed key differences in composition and biological function of the SWI/SNF complex in the two major phyla of Kingdom Fungi.

Citing Articles

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