Dynorphins in Development and Disease: Implications for Cardiovascular Disease

Overview

Journal Curr Mol Med

Publisher Bentham Science Publishers

Specialty Molecular Biology

Date 2019 Nov 21

PMID 31746302

Citations 4

Authors

Cody Cissom

Jason J Paris

Zia Shariat-Madar

Affiliations

Soon will be listed here.

Abstract

It is well-established that cardiovascular disease continues to represent a growing health problem and significant effort has been made to elucidate the underlying mechanisms. In this review, we report on past and recent high impact publications in the field of intracrine network signaling, focusing specifically on opioids and their interrelation with key modulators of the cardiovascular system and the onset of related disease. We present an overview of studies outlining the scope of cardiovascular and cerebrovascular processes that are affected by opioids, including heart function, ischemia, reperfusion, and blood flow. Specific emphasis is placed on the importance of dynorphin molecules in cerebrovascular and cardiovascular regulation. Evidence suggests that excessive or insufficient dynorphin could make an important contribution to cardiovascular physiology, yet numerous paradoxical observations frequently impede a clear understanding of the role of dynorphin. Thus, we argue that dynorphin-mediated signaling events for which an immediate regulatory effect is disputed should not be dismissed as unimportant, as they may play a role in cross-talk with other signaling networks. Finally, we consider the most recent evidence on the role of dynorphin during cardiovascular-related inflammation and on the potential value of endogenous and exogenous inhibitors of kappa-opioid receptor, a major dynorphin A receptor, to limit or prevent cardiovascular disease and its related sequelae.

Citing Articles

The Role of Pro-Opiomelanocortin Derivatives in the Development of Type 2 Diabetes-Associated Myocardial Infarction: Possible Links with Prediabetes.

Gumede N, Khathi A Biomedicines. 2024; 12(2).

PMID: 38397916 PMC: 10887103. DOI: 10.3390/biomedicines12020314.

Integrated transcriptomics contrasts fatty acid metabolism with hypoxia response in β-cell subpopulations associated with glycemic control.

Miranda M, Macias-Velasco J, Schmidt H, Lawson H BMC Genomics. 2023; 24(1):156.

PMID: 36978008 PMC: 10052828. DOI: 10.1186/s12864-023-09232-5.

Endogenous Opioids and Their Role in Stem Cell Biology and Tissue Rescue.

Petrocelli G, Pampanella L, Abruzzo P, Ventura C, Canaider S, Facchin F Int J Mol Sci. 2022; 23(7).

PMID: 35409178 PMC: 8998234. DOI: 10.3390/ijms23073819.

Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease.

Ferrario C, Ahmad S, Groban L Clin Sci (Lond). 2020; 134(19):2645-2664.

PMID: 33063823 PMC: 9055624. DOI: 10.1042/CS20200901.

References

Mannelli M, Maggi M, DeFeo M, Boscaro M, Opocher G, Mantero F . Opioid modulation of normal and pathological human chromaffin tissue. J Clin Endocrinol Metab. 1986; 62(3):577-82. DOI: 10.1210/jcem-62-3-577. View

Edenberg H, Wang J, Tian H, Pochareddy S, Xuei X, Wetherill L . A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence. Hum Mol Genet. 2008; 17(12):1783-9. PMC: 2405904. DOI: 10.1093/hmg/ddn068. View

Ventura C, Pintus G . Opioid peptide gene expression in the primary hereditary cardiomyopathy of the Syrian hamster. III. Autocrine stimulation of prodynorphin gene expression by dynorphin B. J Biol Chem. 1997; 272(10):6699-705. DOI: 10.1074/jbc.272.10.6699. View

Horikawa S, Takai T, Toyosato M, Takahashi H, Noda M, Kakidani H . Isolation and structural organization of the human preproenkephalin B gene. Nature. 1983; 306(5943):611-4. DOI: 10.1038/306611a0. View

Silvani A, Calandra-Buonaura G, Dampney R, Cortelli P . Brain-heart interactions: physiology and clinical implications. Philos Trans A Math Phys Eng Sci. 2016; 374(2067). DOI: 10.1098/rsta.2015.0181. View

Spampinato S, Paradisi R, Canossa M, Campana G, FRANK G, Flamigni C . Immunoreactive dynorphin A-like material in extracted human hypothalamic-hypophysial plasma. Life Sci. 1993; 52(2):223-30. DOI: 10.1016/0024-3205(93)90143-q. View

Rostamzadeh F, Najafipour H, Yeganeh-Hajahmadi M, Esmaeili-Mahani S, Joukar S, Iranpour M . Heterodimerization of apelin and opioid receptors and cardiac inotropic and lusitropic effects of apelin in 2K1C hypertension: Role of pERK1/2 and PKC. Life Sci. 2017; 191:24-33. DOI: 10.1016/j.lfs.2017.09.044. View

Krazinski B, Koziorowski M, Brzuzan P, Okrasa S . The expression of genes encoding opioid precursors and the influence of opioid receptor agonists on steroidogenesis in porcine adrenocortical cells in vitro. J Physiol Pharmacol. 2011; 62(4):461-8. View

Camacho P, Fan H, Liu Z, He J . Large Mammalian Animal Models of Heart Disease. J Cardiovasc Dev Dis. 2018; 3(4). PMC: 5715721. DOI: 10.3390/jcdd3040030. View

10.

Feng Y, He X, Yang Y, Chao D, Lazarus L, Xia Y . Current research on opioid receptor function. Curr Drug Targets. 2011; 13(2):230-46. PMC: 3371376. DOI: 10.2174/138945012799201612. View

11.

Maslov L, Lishmanov I, Krylatov A, Ugdyzhekova D . [The participation of the central and peripheral kappa-opiate receptors in the mechanism of the anti-arrhythmia action of benzeneacetamide derivatives]. Eksp Klin Farmakol. 1996; 59(6):20-2. View

12.

Shen M, Zipes D . Role of the autonomic nervous system in modulating cardiac arrhythmias. Circ Res. 2014; 114(6):1004-21. DOI: 10.1161/CIRCRESAHA.113.302549. View

13.

Lee A, Wong T . Effects of dynorphin1-13 on cardiac rhythm and cyclic adenosine monophosphate (cAMP) levels in the isolated perfused rat heart. Neurosci Lett. 1987; 80(3):289-92. DOI: 10.1016/0304-3940(87)90469-1. View

14.

Ventura C, Guarnieri C, Vaona I, Campana G, Pintus G, Spampinato S . Dynorphin gene expression and release in the myocardial cell. J Biol Chem. 1994; 269(7):5384-6. View

15.

Portbury A, Chandra R, Groelle M, McMillian M, Elias A, Herlong J . Catecholamines act via a beta-adrenergic receptor to maintain fetal heart rate and survival. Am J Physiol Heart Circ Physiol. 2003; 284(6):H2069-77. DOI: 10.1152/ajpheart.00588.2002. View

16.

Marinova Z, Vukojevic V, Surcheva S, Yakovleva T, Cebers G, Pasikova N . Translocation of dynorphin neuropeptides across the plasma membrane. A putative mechanism of signal transmission. J Biol Chem. 2005; 280(28):26360-70. DOI: 10.1074/jbc.M412494200. View

17.

Maeda S, Nakamae J, Inoki R . Inhibition of cardiac Na+, K+-ATPase activity by dynorphin-A and ethylketocyclazocine. Life Sci. 1988; 42(4):461-8. DOI: 10.1016/0024-3205(88)90085-9. View

18.

Arendt R, Schmoeckel M, Wilbert-Lampen U, Plasse A, Heucke L, Werdan K . Bidirectional effects of endogenous opioid peptides on endothelin release rates in porcine aortic endothelial cell culture: mediation by delta opioid receptor and opioid receptor antagonist-insensitive mechanisms. J Pharmacol Exp Ther. 1995; 272(1):1-7. View

19.

Barnes M, Jen K, Dunbar J . The effect of CNS opioid on autonomic nervous and cardiovascular responses in diet-induced obese rats. Peptides. 2004; 25(1):71-9. DOI: 10.1016/j.peptides.2003.11.009. View

20.

Ventura C, Pintus G, Vaona I, Bennardini F, Pinna G, Tadolini B . Phorbol ester regulation of opioid peptide gene expression in myocardial cells. Role of nuclear protein kinase. J Biol Chem. 1995; 270(50):30115-20. DOI: 10.1074/jbc.270.50.30115. View