Marrow Fat-Secreted Factors As Biomarkers for Osteoporosis

Overview

Journal Curr Osteoporos Rep

Publisher Current Science

Specialties Endocrinology
Orthopedics

Date 2019 Nov 18

PMID 31734905

Citations 18

Authors

Markus Herrmann

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: The age-related accumulation of bone marrow adipose tissue (BMAT) negatively impacts bone metabolism and hematopoiesis. This review provides an overview about BMAT-secreted factors as biomarkers for BMAT accumulation and osteoporosis risk.

Recent Findings: The adipokines leptin and adiponectin are regulators of BMAT. It remains to be clarified if locally produced adipokines substantially contribute to their peripheral serum levels and if they influence bone metabolism beyond that of extraosseous adipokine production. Existing data also suggests that BMAT disturbs bone metabolism primarily through palmitate-mediated toxic effects on osteoblasts and osteocytes, including dysregulated autophagy and apoptosis. BMAT-secreted factors are important modulators of bone metabolism. However, the majority of our understanding about MAT-secreted factors and their paracrine and endocrine effects is derived from in vitro studies and animal experiments. Therefore, more research is needed before BMAT-secreted biomarkers can be applied in medical practice.

Citing Articles

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References

Lonnqvist F, Arner P, Nordfors L, Schalling M . Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med. 1995; 1(9):950-3. DOI: 10.1038/nm0995-950. View

Corre J, Planat-Benard V, Corberand J, Penicaud L, Casteilla L, Laharrague P . Human bone marrow adipocytes support complete myeloid and lymphoid differentiation from human CD34 cells. Br J Haematol. 2004; 127(3):344-7. DOI: 10.1111/j.1365-2141.2004.05198.x. View

Baek K, Bloomfield S . Blocking β-adrenergic signaling attenuates reductions in circulating leptin, cancellous bone mass, and marrow adiposity seen with dietary energy restriction. J Appl Physiol (1985). 2012; 113(11):1792-801. DOI: 10.1152/japplphysiol.00187.2012. View

Hickey M, Houmard J, Considine R, Tyndall G, Midgette J, Gavigan K . Gender-dependent effects of exercise training on serum leptin levels in humans. Am J Physiol. 1997; 272(4 Pt 1):E562-6. DOI: 10.1152/ajpendo.1997.272.4.E562. View

Ryden M, Dicker A, Gotherstrom C, Astrom G, Tammik C, Arner P . Functional characterization of human mesenchymal stem cell-derived adipocytes. Biochem Biophys Res Commun. 2003; 311(2):391-7. DOI: 10.1016/j.bbrc.2003.10.010. View

Kricun M . Red-yellow marrow conversion: its effect on the location of some solitary bone lesions. Skeletal Radiol. 1985; 14(1):10-9. DOI: 10.1007/BF00361188. View

Ukkola O, Santaniemi M . Adiponectin: a link between excess adiposity and associated comorbidities?. J Mol Med (Berl). 2002; 80(11):696-702. DOI: 10.1007/s00109-002-0378-7. View

Clabaut A, Delplace S, Chauveau C, Hardouin P, Broux O . Human osteoblasts derived from mesenchymal stem cells express adipogenic markers upon coculture with bone marrow adipocytes. Differentiation. 2010; 80(1):40-5. DOI: 10.1016/j.diff.2010.04.004. View

Hartjes T, Mytnyk S, Jenster G, Steijn V, van Royen M . Extracellular Vesicle Quantification and Characterization: Common Methods and Emerging Approaches. Bioengineering (Basel). 2019; 6(1). PMC: 6466085. DOI: 10.3390/bioengineering6010007. View

10.

Perez L, Pareja-Galeano H, Sanchis-Gomar F, Emanuele E, Lucia A, Galvez B . 'Adipaging': ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue. J Physiol. 2016; 594(12):3187-207. PMC: 4908019. DOI: 10.1113/JP271691. View

11.

Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau J, Bortoluzzi M . The stomach is a source of leptin. Nature. 1998; 394(6695):790-3. DOI: 10.1038/29547. View

12.

Kugel H, Jung C, Schulte O, Heindel W . Age- and sex-specific differences in the 1H-spectrum of vertebral bone marrow. J Magn Reson Imaging. 2001; 13(2):263-8. DOI: 10.1002/1522-2586(200102)13:2<263::aid-jmri1038>3.0.co;2-m. View

13.

Knutson K, Spiegel K, Penev P, Van Cauter E . The metabolic consequences of sleep deprivation. Sleep Med Rev. 2007; 11(3):163-78. PMC: 1991337. DOI: 10.1016/j.smrv.2007.01.002. View

14.

Elmquist J, Elias C, Saper C . From lesions to leptin: hypothalamic control of food intake and body weight. Neuron. 1999; 22(2):221-32. DOI: 10.1016/s0896-6273(00)81084-3. View

15.

Kranendonk M, Visseren F, van Balkom B, Nolte-t Hoen E, van Herwaarden J, de Jager W . Human adipocyte extracellular vesicles in reciprocal signaling between adipocytes and macrophages. Obesity (Silver Spring). 2013; 22(5):1296-308. DOI: 10.1002/oby.20679. View

16.

Cuminetti V, Arranz L . Bone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Niche. J Clin Med. 2019; 8(5). PMC: 6572059. DOI: 10.3390/jcm8050707. View

17.

Barbour K, Zmuda J, Boudreau R, Strotmeyer E, Horwitz M, Evans R . The effects of adiponectin and leptin on changes in bone mineral density. Osteoporos Int. 2011; 23(6):1699-710. PMC: 3536828. DOI: 10.1007/s00198-011-1768-x. View

18.

Sinha M, Opentanova I, Ohannesian J, Kolaczynski J, Heiman M, Hale J . Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. J Clin Invest. 1996; 98(6):1277-82. PMC: 507552. DOI: 10.1172/JCI118913. View

19.

Schoettl T, Fischer I, Ussar S . Heterogeneity of adipose tissue in development and metabolic function. J Exp Biol. 2018; 221(Pt Suppl 1). DOI: 10.1242/jeb.162958. View

20.

Considine R, Nyce M, Kolaczynski J, Zhang P, Ohannesian J, Moore Jr J . Dexamethasone stimulates leptin release from human adipocytes: unexpected inhibition by insulin. J Cell Biochem. 1997; 65(2):254-8. DOI: 10.1002/(sici)1097-4644(199705)65:2<254::aid-jcb10>3.0.co;2-i. View