What Are the Later Life Contributions to Reserve, Resilience, and Compensation?

Overview

Journal Neurobiol Aging

Publisher Elsevier

Specialties Geriatrics
Neurology
Physiology

Date 2019 Nov 17

PMID 31732017

Citations 15

Authors

Sara N Burke

Elizabeth C Mormino

Emily J Rogalski

Claudia H Kawas

Robert J Willis

Denise C Park

Affiliations

Soon will be listed here.

Abstract

Many studies have shown that early-life experiences can contribute to later life cognitive reserve and resilience. However, there is evidence to suggest that later life experiences and lifestyle choices can also play a vital role in the brain's ability to respond to and compensate for neural insults associated with aging. Engaging in a diversity of behaviorally, socially, and cognitively rich activities may forge new neural pathways that can perhaps provide greater flexibility in confronting the challenges associated with accumulating brain pathology. Studies of cognitively normal individuals with pathology and of individuals who have aged exceptionally well may provide insights that are generalizable to the overall elderly population.

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References

Gefen T, Peterson M, Papastefan S, Martersteck A, Whitney K, Rademaker A . Morphometric and histologic substrates of cingulate integrity in elders with exceptional memory capacity. J Neurosci. 2015; 35(4):1781-91. PMC: 4308613. DOI: 10.1523/JNEUROSCI.2998-14.2015. View

Hernandez A, Maurer A, Reasor J, Turner S, Barthle S, Johnson S . Age-related impairments in object-place associations are not due to hippocampal dysfunction. Behav Neurosci. 2015; 129(5):599-610. PMC: 4945158. DOI: 10.1037/bne0000093. View

Fisher G, Stachowski A, Infurna F, Faul J, Grosch J, Tetrick L . Mental work demands, retirement, and longitudinal trajectories of cognitive functioning. J Occup Health Psychol. 2014; 19(2):231-42. PMC: 4663987. DOI: 10.1037/a0035724. View

Brune M, Schobel A, Karau R, Benali A, Faustmann P, Juckel G . Von Economo neuron density in the anterior cingulate cortex is reduced in early onset schizophrenia. Acta Neuropathol. 2010; 119(6):771-8. DOI: 10.1007/s00401-010-0673-2. View

Rogalski E, Gefen T, Shi J, Samimi M, Bigio E, Weintraub S . Youthful memory capacity in old brains: anatomic and genetic clues from the Northwestern SuperAging Project. J Cogn Neurosci. 2012; 25(1):29-36. PMC: 3541673. DOI: 10.1162/jocn_a_00300. View

Mormino E, Smiljic A, Hayenga A, Onami S, Greicius M, Rabinovici G . Relationships between β-amyloid and functional connectivity in different components of the default mode network in aging. Cereb Cortex. 2011; 21(10):2399-407. PMC: 3169663. DOI: 10.1093/cercor/bhr025. View

Jo Y, Lee I . Disconnection of the hippocampal-perirhinal cortical circuits severely disrupts object-place paired associative memory. J Neurosci. 2010; 30(29):9850-8. PMC: 2913067. DOI: 10.1523/JNEUROSCI.1580-10.2010. View

Dickerson B, Bakkour A, Salat D, Feczko E, Pacheco J, Greve D . The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cereb Cortex. 2008; 19(3):497-510. PMC: 2638813. DOI: 10.1093/cercor/bhn113. View

Maher A, Kielb S, Loyer E, Connelley M, Rademaker A, Mesulam M . Psychological well-being in elderly adults with extraordinary episodic memory. PLoS One. 2017; 12(10):e0186413. PMC: 5653294. DOI: 10.1371/journal.pone.0186413. View

10.

Rohwedder S, Willis R . Mental Retirement. J Econ Perspect. 2010; 24(1):119-138. PMC: 2958696. DOI: 10.1257/jep.24.1.119. View

11.

Gefen T, Shaw E, Whitney K, Martersteck A, Stratton J, Rademaker A . Longitudinal neuropsychological performance of cognitive SuperAgers. J Am Geriatr Soc. 2014; 62(8):1598-600. PMC: 4135532. DOI: 10.1111/jgs.12967. View

12.

Cook A, Sridhar J, Ohm D, Rademaker A, Mesulam M, Weintraub S . Rates of Cortical Atrophy in Adults 80 Years and Older With Superior vs Average Episodic Memory. JAMA. 2017; 317(13):1373-1375. PMC: 5847263. DOI: 10.1001/jama.2017.0627. View

13.

Corrada M, Berlau D, Kawas C . A population-based clinicopathological study in the oldest-old: the 90+ study. Curr Alzheimer Res. 2012; 9(6):709-17. PMC: 3409303. DOI: 10.2174/156720512801322537. View

14.

Kawas C, Corrada M . Alzheimer's and dementia in the oldest-old: a century of challenges. Curr Alzheimer Res. 2006; 3(5):411-9. PMC: 3373256. DOI: 10.2174/156720506779025233. View

15.

Brune M, Schobel A, Karau R, Faustmann P, Dermietzel R, Juckel G . Neuroanatomical correlates of suicide in psychosis: the possible role of von Economo neurons. PLoS One. 2011; 6(6):e20936. PMC: 3120769. DOI: 10.1371/journal.pone.0020936. View

16.

Burke S, Wallace J, Nematollahi S, Uprety A, Barnes C . Pattern separation deficits may contribute to age-associated recognition impairments. Behav Neurosci. 2010; 124(5):559-73. PMC: 3071152. DOI: 10.1037/a0020893. View

17.

Burke S, Hartzell A, Lister J, Hoang L, Barnes C . Layer V perirhinal cortical ensemble activity during object exploration: a comparison between young and aged rats. Hippocampus. 2012; 22(10):2080-93. PMC: 3523702. DOI: 10.1002/hipo.22066. View

18.

Seeley W, Carlin D, Allman J, Macedo M, Bush C, Miller B . Early frontotemporal dementia targets neurons unique to apes and humans. Ann Neurol. 2006; 60(6):660-7. DOI: 10.1002/ana.21055. View

19.

Rogalski E, Gefen T, Mao Q, Connelly M, Weintraub S, Geula C . Cognitive trajectories and spectrum of neuropathology in SuperAgers: The first 10 cases. Hippocampus. 2018; 29(5):458-467. PMC: 6050141. DOI: 10.1002/hipo.22828. View

20.

Harrison T, Weintraub S, Mesulam M, Rogalski E . Superior memory and higher cortical volumes in unusually successful cognitive aging. J Int Neuropsychol Soc. 2012; 18(6):1081-5. PMC: 3547607. DOI: 10.1017/S1355617712000847. View