Synthesis and Antibacterial Properties of Novel ZnMnO-Chitosan Nanocomposites

Overview

Journal Nanomaterials (Basel)

Date 2019 Nov 14

PMID 31717589

Citations 6

Authors

Rajiv Gandhi Packirisamy

Chandramohan Govindasamy

Anandhavelu Sanmugam

K Karuppasamy

Hyun-Seok Kim

Dhanasekaran Vikraman

Affiliations

Soon will be listed here.

Abstract

The development of productive antibacterial agents from nontoxic materials via a simple methodology has been an immense research contribution in the medicinal chemistry field. Herein, a sol-gel one-pot reaction was used to synthesize hybrid composites of hausmannite-chitosan (MnO-CS) and its innovative derivative zinc manganese oxide-chitosan (ZnMnO-CS). Fixed amounts of CS with different metal matrix / ratios of 0.5%, 1.0%, 1.5%, and 2.0% for Mn and Zn precursors were used to synthesize ZnMnO-CS hybrid composites. X-ray diffraction analysis indicated the formation of polycrystalline tetragonal-structured ZnMnO with a CS matrix in the hybrids. Fourier-transform infrared spectroscopic analysis confirmed the formation of ZnMnO-CS hybrids. Detailed investigations of the surface modifications were conducted using scanning electron microscopy; micrographs at different magnifications revealed that the composites' surface changed depending on the ratio of the source materials used to synthesize the ZnMnO-CS hybrids. The antibacterial activity of the MnO-CS and ZnMnO-CS composites was tested against various bacterial species, including , , , and The zone of inhibition and minimum inhibitory concentration values were deduced to demonstrate the efficacy of the ZnMnO-CS nanocomposites as antibacterial agents.

Citing Articles

Chitosan-Based Multifunctional Biomaterials as Active Agents or Delivery Systems for Antibacterial Therapy.

Wang M, Wang Y, Chen G, Gao H, Peng Q Bioengineering (Basel). 2025; 11(12.

PMID: 39768096 PMC: 11673874. DOI: 10.3390/bioengineering11121278.

Chitosan-Integrated Curcumin-Graphene Oxide/Copper Oxide Hybrid Nanocomposites for Antibacterial and Cytotoxicity Applications.

Sanmugam A, Sellappan L, Sridharan A, Manoharan S, Sairam A, Almansour A Antibiotics (Basel). 2024; 13(7).

PMID: 39061302 PMC: 11273410. DOI: 10.3390/antibiotics13070620.

Development of ZnO/selenium nanoparticles embedded chitosan-based anti-bacterial wound dressing for potential healing ability and nursing care after paediatric fracture surgery.

Ruan Q, Yuan L, Gao S, Ji X, Shao W, Ma J Int Wound J. 2023; 20(6):1819-1831.

PMID: 36992557 PMC: 10333019. DOI: 10.1111/iwj.13947.

Biopolymeric NiS/AgS/TiO/Calcium Alginate Aerogel for the Decontamination of Pharmaceutical Drug and Microbial Pollutants from Wastewater.

Kumar R, Oves M, Ansari M, Taleb M, Baraka M, Alghamdi M Nanomaterials (Basel). 2022; 12(20).

PMID: 36296832 PMC: 9609712. DOI: 10.3390/nano12203642.

Antibacterial Activity of Nanoparticles.

Truong V, Truong N, Rice S Nanomaterials (Basel). 2021; 11(6).

PMID: 34070314 PMC: 8225165. DOI: 10.3390/nano11061391.

References

Enescu D, Cerqueira M, Fucinos P, Pastrana L . Recent advances and challenges on applications of nanotechnology in food packaging. A literature review. Food Chem Toxicol. 2019; 134:110814. DOI: 10.1016/j.fct.2019.110814. View

Chowdhury A, Azam M, Aktaruzzaman M, Rahim A . Oxidative and antibacterial activity of Mn3O4. J Hazard Mater. 2009; 172(2-3):1229-35. DOI: 10.1016/j.jhazmat.2009.07.129. View

Chatterjee A, Modarai M, Naylor N, Boyd S, Atun R, Barlow J . Quantifying drivers of antibiotic resistance in humans: a systematic review. Lancet Infect Dis. 2018; 18(12):e368-e378. DOI: 10.1016/S1473-3099(18)30296-2. View

Alavi M, Karimi N . Ultrasound assisted-phytofabricated FeO NPs with antioxidant properties and antibacterial effects on growth, biofilm formation, and spreading ability of multidrug resistant bacteria. Artif Cells Nanomed Biotechnol. 2019; 47(1):2405-2423. DOI: 10.1080/21691401.2019.1624560. View

Konwar A, Kalita S, Kotoky J, Chowdhury D . Chitosan-Iron Oxide Coated Graphene Oxide Nanocomposite Hydrogel: A Robust and Soft Antimicrobial Biofilm. ACS Appl Mater Interfaces. 2016; 8(32):20625-34. DOI: 10.1021/acsami.6b07510. View

Nathan C, Cunningham-Bussel A . Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nat Rev Immunol. 2013; 13(5):349-61. PMC: 4250048. DOI: 10.1038/nri3423. View

Xie Y, He Y, Irwin P, Jin T, Shi X . Antibacterial activity and mechanism of action of zinc oxide nanoparticles against Campylobacter jejuni. Appl Environ Microbiol. 2011; 77(7):2325-31. PMC: 3067441. DOI: 10.1128/AEM.02149-10. View

Amaral I, Granja P, Barbosa M . Chemical modification of chitosan by phosphorylation: an XPS, FT-IR and SEM study. J Biomater Sci Polym Ed. 2005; 16(12):1575-93. DOI: 10.1163/156856205774576736. View

Oloke J . Activity pattern of natural and synthetic antibacterial agents among hospital isolates. Microbios. 2000; 102(403):175-81. View

10.

Sirelkhatim A, Mahmud S, Seeni A, Kaus N, Ann L, Mohd Bakhori S . Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism. Nanomicro Lett. 2018; 7(3):219-242. PMC: 6223899. DOI: 10.1007/s40820-015-0040-x. View

11.

Packirisamy R, Govindasamy C, Sanmugam A, Venkatesan S, Kim H, Vikraman D . Synthesis of novel SnZnO-chitosan nanocomposites: Structural, morphological and luminescence properties and investigation of antibacterial properties. Int J Biol Macromol. 2019; 138:546-555. DOI: 10.1016/j.ijbiomac.2019.07.120. View

12.

Andiappan K, Sanmugam A, Deivanayagam E, Karuppasamy K, Kim H, Vikraman D . Schiff base rare earth metal complexes: Studies on functional, optical and thermal properties and assessment of antibacterial activity. Int J Biol Macromol. 2018; 124:403-410. DOI: 10.1016/j.ijbiomac.2018.11.251. View

13.

Besinis A, Peralta T, Handy R . The antibacterial effects of silver, titanium dioxide and silica dioxide nanoparticles compared to the dental disinfectant chlorhexidine on Streptococcus mutans using a suite of bioassays. Nanotoxicology. 2012; 8(1):1-16. PMC: 3878355. DOI: 10.3109/17435390.2012.742935. View

14.

Bera R, Mandal S, Raj C . Antimicrobial activity of fluorescent Ag nanoparticles. Lett Appl Microbiol. 2014; 58(6):520-6. DOI: 10.1111/lam.12222. View

15.

Houghton F . Antimicrobial resistance (AMR) and the United Nations (UN). J Infect Public Health. 2016; 10(1):139-140. DOI: 10.1016/j.jiph.2016.10.002. View

16.

Andiappan K, Sanmugam A, Deivanayagam E, Karuppasamy K, Kim H, Vikraman D . In vitro cytotoxicity activity of novel Schiff base ligand-lanthanide complexes. Sci Rep. 2018; 8(1):3054. PMC: 5812993. DOI: 10.1038/s41598-018-21366-1. View

17.

Feng Q, Wu J, Chen G, Cui F, Kim T, Kim J . A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus. J Biomed Mater Res. 2000; 52(4):662-8. DOI: 10.1002/1097-4636(20001215)52:4<662::aid-jbm10>3.0.co;2-3. View

18.

Sugden R, Kelly R, Davies S . Combatting antimicrobial resistance globally. Nat Microbiol. 2016; 1(10):16187. DOI: 10.1038/nmicrobiol.2016.187. View

19.

Xia T, Kovochich M, Liong M, Madler L, Gilbert B, Shi H . Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano. 2009; 2(10):2121-34. PMC: 3959800. DOI: 10.1021/nn800511k. View

20.

Soderberg T, Sunzel B, Holm S, Elmros T, Hallmans G, Sjoberg S . Antibacterial effect of zinc oxide in vitro. Scand J Plast Reconstr Surg Hand Surg. 1990; 24(3):193-7. DOI: 10.3109/02844319009041278. View