Chitosan-Integrated Curcumin-Graphene Oxide/Copper Oxide Hybrid Nanocomposites for Antibacterial and Cytotoxicity Applications

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2024 Jul 27

PMID 39061302

Authors

Anandhavelu Sanmugam

Logesh Kumar Sellappan

Abbishek Sridharan

Swathy Manoharan

Ananda Babu Sairam

Abdulrahman I Almansour

Subha Veerasundaram

Hyun-Seok Kim

Dhanasekaran Vikraman

Affiliations

Soon will be listed here.

Abstract

This study deals with the facile synthesis of a single-pot chemical technique for chitosan-curcumin (CUR)-based hybrid nanocomposites with nanostructured graphene oxide (GO) and copper oxide (CuO) as the antibacterial and cytotoxic drugs. The physicochemical properties of synthesized hybrid nanocomposites such as CS-GO, CS-CuO, CS-CUR-GO, and CS-CUR-GO/CuO were confirmed with various advanced tools. Moreover, the in vitro drug release profile of the CS-CUR-GO/CuO nanocomposite exhibited sustained and controlled release during different time intervals. Also, the antibacterial activity of the CS-CUR-GO/CuO hybrid nanocomposite presented the maximum bactericidal effect against and pathogens. The hybrid nanocomposites revealed improved cytotoxicity behaviour against cultured mouse fibroblast cells (L929) via cell adhesion, DNA damage, and proliferation. Thus, the chitosan-based hybrid nanocomposites offer rich surface area, biocompatibility, high oxidative stress, and bacterial cell disruption functionalities as a potential candidate for antibacterial and cytotoxicity applications.

Citing Articles

Facile fabrication of a novel chitosan/carboxymethyl cellulose/bentonite/CuO nanocomposite for enhanced photocatalytic and antibacterial applications.

Khandelwal M, Soni K, Misra K, Bagaria A, Rathore D, Pemawat G RSC Adv. 2025; 15(5):3365-3377.

PMID: 39902111 PMC: 11788891. DOI: 10.1039/d4ra08437c.

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