Paracrine Signalling of AGR2 Stimulates RhoA Function in Fibroblasts and Modulates Cell Elongation and Migration

Overview

Journal Cell Adh Migr

Specialty Cell Biology

Date 2019 Nov 12

PMID 31710263

Citations 4

Authors

Hitesh Bhagavanbhai Mangukiya

Hema Negi

Siva Bharath Merugu

Qudsia Sehar

Dhahiri Saidi Mashausi

Fakhar-Un-Nisa Yunus

Zhenghua Wu

Dawei Li

Affiliations

Soon will be listed here.

Abstract

The most prominent cancer-associated fibroblasts (CAFs) in tumor stroma is known to form a protective structure to support tumor growth. Anterior gradient-2 (AGR2), a tumor secretory protein is believed to play a pivotal role during tumor microenvironment (TME) development. Here, we report that extracellular AGR2 enhances fibroblasts elongation and migration significantly. The early stimulation of RhoA showed the association of AGR2 by upregulation of G1-S phase-regulatory protein cyclin D1 and FAK phosphorylation through fibroblasts growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR). Our finding indicates that secretory AGR2 alters fibroblasts elongation, migration, and organization suggesting the secretory AGR2 as a potential molecular target that might be responsible to alter fibroblasts infiltration to support tumor growth.

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