Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction

Overview

Journal JACC Basic Transl Sci

Date 2019 Nov 12

PMID 31709319

Citations 12

Authors

Yuya Ide

Takahiro Horie

Naritatsu Saito

Shin Watanabe

Chiharu Otani

Yui Miyasaka

Yasuhide Kuwabara

Tomohiro Nishino

Tetsushi Nakao

Masataka Nishiga

Hitoo Nishi

Yasuhiro Nakashima

Fumiko Nakazeki

Satoshi Koyama

Masahiro Kimura

Shuhei Tsuji

Randolph Ruiz Rodriguez

Sijia Xu

Tomohiro Yamasaki

Toshimitsu Watanabe

Masamichi Yamamoto

Motoko Yanagita

Takeshi Kimura

Akira Kakizuka

Koh Ono

Affiliations

Soon will be listed here.

Abstract

No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyoto University Substance 121 (KUS121) reduced endoplasmic reticulum stress, maintained adenosine triphosphate levels, and ameliorated the infarct size in a murine cardiac ischemia and reperfusion injury model. The study confirmed the cardioprotective effect of KUS121 in a porcine ischemia and reperfusion injury model. These findings confirmed that KUS121 is a promising novel therapeutic agent for myocardial infarction in conjunction with primary percutaneous coronary intervention.

Citing Articles

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