Corticostriatal Flow of Action Selection Bias

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2019 Nov 11

PMID 31706697

Citations 18

Authors

Eun Jung Hwang

Trevor D Link

Yvonne Yuling Hu

Shan Lu

Eric Hou-Jen Wang

Varoth Lilascharoen

Sage Aronson

Keelin ONeil

Byung Kook Lim

Takaki Komiyama

Affiliations

Soon will be listed here.

Abstract

The posterior parietal cortex (PPC) performs many functions, including decision making and movement control. It remains unknown which input and output pathways of PPC support different functions. We addressed this issue in mice, focusing on PPC neurons projecting to the dorsal striatum (PPC-STR) and the posterior secondary motor cortex (PPC-pM2). Projection-specific, retrograde labeling showed that PPC-STR and PPC-pM2 represent largely distinct subpopulations, with PPC-STR receiving stronger inputs from association areas and PPC-pM2 receiving stronger sensorimotor inputs. Two-photon calcium imaging during decision making revealed that the PPC-STR population encodes history-dependent choice bias more strongly than PPC-pM2 or general PPC populations. Furthermore, optogenetic inactivation of PPC-STR neurons or their terminals in STR decreased history-dependent bias, while inactivation of PPC-pM2 neurons altered movement kinematics. Therefore, PPC biases action selection through its STR projection while controlling movements through PPC-pM2 neurons. PPC may support multiple functions through parallel subpopulations, each with distinct input-output connectivity.

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