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Plastic Binding Feature of Polymyxins: the Effect on MIC Susceptibility Measurements

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Publisher Dove Medical Press
Date 2019 Nov 8
PMID 31695440
Citations 11
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Abstract

The loss of polycationic antimicrobial peptides, polymyxins, due to adhesion to plastics is an important subject matter that influences in vitro susceptibility testing, including minimum inhibitory concentration (MIC) assays. This review reminds us that this issue can serve as a significant source of variation in the MIC values for polymyxins against Gram-negative bacteria.

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