Variants in and 3'-s Associated with Reproductive Traits in a Large White Pig Population

Overview

Journal Animals (Basel)

Date 2019 Nov 6

PMID 31683967

Citations 6

Authors

Hang Yin

Xing Du

Qiqi Li

Zengxiang Pan

Wangjun Wu

Honglin Liu

Qifa Li

Affiliations

Soon will be listed here.

Abstract

Bone morphogenetic protein 7 () and , which encode members of the BMP family, have been identified by whole-genome resequencing as breeding-related genes that overlap with a known quantitative trait locus for reproductive traits. In this study, we investigated the effects of variants at the and gene loci on sow reproductive traits. We isolated 669 and 1213 bp sequences of the 3'-untranslated region (3'-) of the porcine and genes, respectively, and detected several RNA regulatory elements, such as miRNA response elements and AU-rich elements. Pooled DNA sequencing identified two novel point mutations (viz., c.1569A>G and c.2366G>A) in the 3'-. Association analysis showed that the c.1569A>G polymorphism was associated with the litter weight trait in a Large White pig population. Furthermore, analysis of the combined genetic effects revealed that / and AG/ were the favorable combined genotypes for the total number of piglets born (TNB) and the total number of piglets born alive (NBA), whereas. Together, our findings confirm that and are candidate genes for porcine reproductive performance.

Citing Articles

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