Germinal Centre B Cell Functions and Lymphomagenesis: Circuits Involving MYC and MicroRNAs

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2019 Nov 6

PMID 31683676

Citations 11

Authors

Marcela Cristina Robaina

Luciano Mazzoccoli

Claudete Esteves Klumb

Affiliations

Soon will be listed here.

Abstract

Background: The transcription factor MYC regulates several biological cellular processes, and its target gene network comprises approximately 15% of all human genes, including microRNAs (miRNAs), that also contribute to MYC regulatory activity. Although miRNAs are emerging as key regulators of immune functions, the specific roles of miRNAs in the regulation/dysregulation of germinal centre B-cells and B-cell lymphomas are still being uncovered. The regulatory network that integrates MYC, target genes and miRNAs is a field of intense study, highlighting potential pathways to be explored in the context of future clinical approaches.

Methods: The scientific literature that is indexed in PUBMED was consulted for publications involving MYC and miRNAs with validated bioinformatics analyses or experimental protocols. Additionally, seminal studies on germinal centre B-cell functions and lymphomagenesis were reported.

Conclusions: This review summarizes the interactions between MYC and miRNAs through regulatory loops and circuits involving target genes in germinal centre B-cell lymphomas with MYC alterations. Moreover, we provide an overview of the understanding of the regulatory networks between MYC and miRNAs, highlighting the potential implication of this approach for the comprehension of germinal centre B-cell lymphoma pathogenesis. Therefore, circuits involving MYC, target genes and miRNAs provide novel insight into lymphomagenesis that could be useful for new improved therapeutic strategies.

Citing Articles

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Unravelling B cell heterogeneity: insights into flow cytometry-gated B cells from single-cell multi-omics data.

Pernes J, Alsayah A, Tucci F, Bashford-Rogers R Front Immunol. 2024; 15:1380386.

PMID: 38707902 PMC: 11067501. DOI: 10.3389/fimmu.2024.1380386.

The RNA helicase DDX3 and its role in c-MYC driven germinal center-derived B-cell lymphoma.

Lacroix M, Beauchemin H, Khandanpour C, Moroy T Front Oncol. 2023; 13:1148936.

PMID: 37035206 PMC: 10081492. DOI: 10.3389/fonc.2023.1148936.

ArtinM Cytotoxicity in B Cells Derived from Non-Hodgkin's Lymphoma Depends on Syk and Src Family Kinases.

Barboza B, Thomaz S, Junior A, Espreafico E, Miyamoto J, Tashima A Int J Mol Sci. 2023; 24(2).

PMID: 36674590 PMC: 9863955. DOI: 10.3390/ijms24021075.

CircRNAs: Roles in regulating head and neck squamous cell carcinoma.

Han X, Tian R, Wang C, Li Y, Song X Front Oncol. 2022; 12:1026073.

PMID: 36483049 PMC: 9723173. DOI: 10.3389/fonc.2022.1026073.

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