β-Catenin: A Metazoan Filter for Biological Noise?

Overview

Journal Front Genet

Date 2019 Nov 5

PMID 31681432

Citations 5

Authors

Saba Rezaei-Lotfi

Neil Hunter

Ramin M Farahani

Affiliations

Soon will be listed here.

Abstract

Molecular noise refers to fluctuations of biological signals that facilitate phenotypic heterogeneity in a population. While endogenous mechanisms exist to limit genetic noise in biological systems, such restrictions are sometimes removed to propel phenotypic variability as an adaptive strategy. Herein, we review evidence for the potential role of β-catenin in restricting gene expression noise by transcriptional and post-transcriptional mechanisms. We discuss mechanisms that restrict intrinsic noise subsequent to nuclear mobilization of β-catenin. Nuclear β-catenin promotes initiation of transcription but buffers against the resultant noise by restraining transcription elongation. Acceleration of cell cycle, mediated Wnt/β-catenin downstream signals, further diminishes intrinsic noise by curtailing the efficiency of protein synthesis. Extrinsic noise, on the other hand, is restricted by β-catenin-mediated regulation of major cellular stress pathways.

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