Control of Cancer Formation by Intrinsic Genetic Noise and Microenvironmental Cues

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2015 Jul 10

PMID 26156637

Citations 33

Authors

Amy Brock

Silva Krause

Donald E Ingber

Affiliations

Soon will be listed here.

Abstract

Differentiation therapies that induce malignant cells to stop growing and revert to normal tissue-specific differentiated cell types are successful in the treatment of a few specific haematological tumours. However, this approach has not been widely applied to solid tumours because their developmental origins are less well understood. Recent advances suggest that understanding tumour cell plasticity and how intrinsic factors (such as genetic noise and microenvironmental signals, including physical cues from the extracellular matrix) govern cell state switches will help in the development of clinically relevant differentiation therapies for solid cancers.

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