RF Heating of Deep Brain Stimulation Implants in Open-bore Vertical MRI Systems: A Simulation Study with Realistic Device Configurations

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2019 Nov 3

PMID 31677308

Citations 16

Authors

Laleh Golestanirad

Ehsan Kazemivalipour

David Lampman

Hideta Habara

Ergin Atalar

Joshua Rosenow

Julie Pilitsis

John Kirsch

Affiliations

Soon will be listed here.

Abstract

Purpose: Patients with deep brain stimulation (DBS) implants benefit highly from MRI, however, access to MRI is restricted for these patients because of safety hazards associated with RF heating of the implant. To date, all MRI studies on RF heating of medical implants have been performed in horizontal closed-bore systems. Vertical MRI scanners have a fundamentally different distribution of electric and magnetic fields and are now available at 1.2T, capable of high-resolution structural and functional MRI. This work presents the first simulation study of RF heating of DBS implants in high-field vertical scanners.

Methods: We performed finite element electromagnetic simulations to calculate specific absorption rate (SAR) at tips of DBS leads during MRI in a commercially available 1.2T vertical coil compared to a 1.5T horizontal scanner. Both isolated leads and fully implanted systems were included.

Results: We found 10- to 30-fold reduction in SAR implication at tips of isolated DBS leads, and up to 19-fold SAR reduction at tips of leads in fully implanted systems in vertical coils compared to horizontal birdcage coils.

Conclusions: If confirmed in larger patient cohorts and verified experimentally, this result can open the door to plethora of structural and functional MRI applications to guide, interpret, and advance DBS therapy.

Citing Articles

Low-field MRI's Spark on Implant Safety: A Closer Look at Radiofrequency Heating.

Sanpitak P, Bhusal B, Vu J, Golestanirad L Annu Int Conf IEEE Eng Med Biol Soc. 2023; 2023:1-5.

PMID: 38083021 PMC: 10842192. DOI: 10.1109/EMBC40787.2023.10340861.

Rapid prediction of MRI-induced RF heating of active implantable medical devices using machine learning.

Vu J, Sanpitak P, Bhusal B, Jiang F, Golestanirad L Annu Int Conf IEEE Eng Med Biol Soc. 2023; 2023:1-4.

PMID: 38082837 PMC: 10848153. DOI: 10.1109/EMBC40787.2023.10340900.

Modifying the trajectory of epicardial leads can substantially reduce MRI-induced RF heating in pediatric patients with a cardiac implantable electronic device at 1.5T.

Jiang F, Bhusal B, Nguyen B, Monge M, Webster G, Kim D Magn Reson Med. 2023; 90(6):2510-2523.

PMID: 37526134 PMC: 10863853. DOI: 10.1002/mrm.29776.

Effect of field strength on RF power deposition near conductive leads: A simulation study of SAR in DBS lead models during MRI at 1.5 T-10.5 T.

Kazemivalipour E, Sadeghi-Tarakameh A, Keil B, Eryaman Y, Atalar E, Golestanirad L PLoS One. 2023; 18(1):e0280655.

PMID: 36701285 PMC: 9879463. DOI: 10.1371/journal.pone.0280655.

A comparative study of RF heating of deep brain stimulation devices in vertical vs. horizontal MRI systems.

Vu J, Bhusal B, Nguyen B, Sanpitak P, Nowac E, Pilitsis J PLoS One. 2022; 17(12):e0278187.

PMID: 36490249 PMC: 9733854. DOI: 10.1371/journal.pone.0278187.

References

Malone Jr D, Dougherty D, Rezai A, Carpenter L, Friehs G, Eskandar E . Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression. Biol Psychiatry. 2008; 65(4):267-75. PMC: 3486635. DOI: 10.1016/j.biopsych.2008.08.029. View

Rezai A, Phillips M, Baker K, Sharan A, Nyenhuis J, Tkach J . Neurostimulation system used for deep brain stimulation (DBS): MR safety issues and implications of failing to follow safety recommendations. Invest Radiol. 2004; 39(5):300-3. DOI: 10.1097/01.rli.0000124940.02340.ab. View

Limousin P, Greene J, Pollak P, Rothwell J, Benabid A, Frackowiak R . Changes in cerebral activity pattern due to subthalamic nucleus or internal pallidum stimulation in Parkinson's disease. Ann Neurol. 1997; 42(3):283-91. DOI: 10.1002/ana.410420303. View

Golestanirad L, Kazemivalipour E, Keil B, Downs S, Kirsch J, Elahi B . Reconfigurable MRI coil technology can substantially reduce RF heating of deep brain stimulation implants: First in-vitro study of RF heating reduction in bilateral DBS leads at 1.5 T. PLoS One. 2019; 14(8):e0220043. PMC: 6685612. DOI: 10.1371/journal.pone.0220043. View

Yeung C, Susil R, Atalar E . RF heating due to conductive wires during MRI depends on the phase distribution of the transmit field. Magn Reson Med. 2002; 48(6):1096-8. DOI: 10.1002/mrm.10310. View

Kazemivalipour E, Keil B, Vali A, Rajan S, Elahi B, Atalar E . Reconfigurable MRI technology for low-SAR imaging of deep brain stimulation at 3T: Application in bilateral leads, fully-implanted systems, and surgically modified lead trajectories. Neuroimage. 2019; 199:18-29. PMC: 7266624. DOI: 10.1016/j.neuroimage.2019.05.015. View

Eryaman Y, Abaci Turk E, Oto C, Algin O, Atalar E . Reduction of the radiofrequency heating of metallic devices using a dual-drive birdcage coil. Magn Reson Med. 2012; 69(3):845-52. DOI: 10.1002/mrm.24316. View

Golestanirad L, Angelone L, Kirsch J, Downs S, Keil B, Bonmassar G . Reducing RF-induced Heating near Implanted Leads through High-Dielectric Capacitive Bleeding of Current (CBLOC). IEEE Trans Microw Theory Tech. 2019; 67(3):1265-1273. PMC: 6788634. DOI: 10.1109/TMTT.2018.2885517. View

McElcheran C, Yang B, Anderson K, Golestanirad L, Graham S . Parallel radiofrequency transmission at 3 tesla to improve safety in bilateral implanted wires in a heterogeneous model. Magn Reson Med. 2017; 78(6):2406-2415. DOI: 10.1002/mrm.26622. View

10.

Horn A . The impact of modern-day neuroimaging on the field of deep brain stimulation. Curr Opin Neurol. 2019; 32(4):511-520. DOI: 10.1097/WCO.0000000000000679. View

11.

Hancu I, Boutet A, Fiveland E, Ranjan M, Prusik J, DiMarzio M . On the (Non-)equivalency of monopolar and bipolar settings for deep brain stimulation fMRI studies of Parkinson's disease patients. J Magn Reson Imaging. 2018; 49(6):1736-1749. DOI: 10.1002/jmri.26321. View

12.

Tagliati M, Jankovic J, Pagan F, Susatia F, Isaias I, Okun M . Safety of MRI in patients with implanted deep brain stimulation devices. Neuroimage. 2009; 47 Suppl 2:T53-7. DOI: 10.1016/j.neuroimage.2009.04.044. View

13.

Holtzheimer P, Kelley M, Gross R, Filkowski M, Garlow S, Barrocas A . Subcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression. Arch Gen Psychiatry. 2012; 69(2):150-8. PMC: 4423545. DOI: 10.1001/archgenpsychiatry.2011.1456. View

14.

Golestanirad L, Angelone L, Iacono M, Katnani H, Wald L, Bonmassar G . Local SAR near deep brain stimulation (DBS) electrodes at 64 and 127 MHz: A simulation study of the effect of extracranial loops. Magn Reson Med. 2016; 78(4):1558-1565. PMC: 5411348. DOI: 10.1002/mrm.26535. View

15.

Serano P, Angelone L, Katnani H, Eskandar E, Bonmassar G . A novel brain stimulation technology provides compatibility with MRI. Sci Rep. 2015; 5:9805. PMC: 4413880. DOI: 10.1038/srep09805. View

16.

Moeschler S, Sanders R, Hooten W, Hoelzer B . Spinal cord stimulator explantation for magnetic resonance imaging: a case series. Neuromodulation. 2014; 18(4):285-8. DOI: 10.1111/ner.12254. View

17.

Jech R, Urgosik D, Tintera J, Nebuzelsky A, Krasensky J, Liscak R . Functional magnetic resonance imaging during deep brain stimulation: a pilot study in four patients with Parkinson's disease. Mov Disord. 2001; 16(6):1126-32. DOI: 10.1002/mds.1217. View

18.

Golestanirad L, Kirsch J, Bonmassar G, Downs S, Elahi B, Martin A . RF-induced heating in tissue near bilateral DBS implants during MRI at 1.5 T and 3T: The role of surgical lead management. Neuroimage. 2018; 184:566-576. PMC: 6475594. DOI: 10.1016/j.neuroimage.2018.09.034. View

19.

Golestanirad L, Iacono M, Keil B, Angelone L, Bonmassar G, Fox M . Construction and modeling of a reconfigurable MRI coil for lowering SAR in patients with deep brain stimulation implants. Neuroimage. 2016; 147:577-588. PMC: 5303648. DOI: 10.1016/j.neuroimage.2016.12.056. View

20.

Carmichael D, Thornton J, Rodionov R, Thornton R, McEvoy A, Ordidge R . Feasibility of simultaneous intracranial EEG-fMRI in humans: a safety study. Neuroimage. 2009; 49(1):379-90. DOI: 10.1016/j.neuroimage.2009.07.062. View