Microvascular Density Under Magnifying Narrow-band Imaging Endoscopy in Colorectal Epithelial Neoplasms

Overview

Journal Intest Res

Date 2019 Nov 2

PMID 31671929

Citations 10

Authors

Takahiro Gonai

Keisuke Kawasaki

Shotaro Nakamura

Shunichi Yanai

Risaburo Akasaka

Kunihiko Sato

Yousuke Toya

Kensuke Asakura

Jun Urushikubo

Yasuko Fujita

Makoto Eizuka

Noriyuki Uesugi

Tamotsu Sugai

Takayuki Matsumoto

Affiliations

Soon will be listed here.

Abstract

Background/aims: Magnifying endoscopic classification systems, such as the Japan narrow-band imaging (NBI) Expert Team (JNET) classification, have been widely used for predicting the histologic diagnosis and invasion depth of colorectal epithelial tumors. However, disagreement exists among observers regarding magnifying endoscopic diagnosis, because these classification systems are subjective. We herein investigated the utility of endoscopic microvascular density (eMVD) calculated from magnifying NBI endoscopic images in colorectal tumors.

Methods: We reviewed magnifying NBI endoscopic images from 169 colorectal epithelial tumors (97 adenomas, 72 carcinomas/high-grade dysplasias) resected endoscopically or surgically. The eMVD on magnifying NBI endoscopic images was evaluated using image-editing software, and relationships between eMVD and clinical, endoscopic, and pathological findings were retrospectively analyzed.

Results: The eMVD in carcinomas (0.152 ± 0.079) was significantly higher than that in adenomas (0.119 ± 0.059, P< 0.05). The best cutoff value for distinguishing carcinoma from adenoma was 0.133. Sensitivity, specificity, and accuracy were 56.9%, 67.0%, and 62.7%, respectively. In addition, JNET type 2B tumors showed significantly higher eMVD (0.162 ± 0.079) compared to type 2A tumors (0.111 ± 0.050, P< 0.05).

Conclusions: The eMVD as determined by magnifying NBI endoscopy is considered to be a possible objective indicator for differentiating colorectal carcinomas from adenomas.

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