Echocardiography Improves Prediction of Major Adverse Cardiovascular Events in a Population with Type 1 Diabetes and Without Known Heart Disease: the Thousand & 1 Study

Overview

Journal Diabetologia

Specialty Endocrinology

Date 2019 Oct 31

PMID 31664481

Citations 11

Authors

Magnus T Jensen

Peter Sogaard

Ida Gustafsson

Jan Bech

Thomas F Hansen

Thomas Almdal

Simone Theilade

Tor Biering-Sorensen

Peter G Jorgensen

Soren Galatius

Henrik U Andersen

Peter Rossing

Affiliations

Soon will be listed here.

Abstract

Aims/hypothesis: Cardiovascular disease is the most common comorbidity in type 1 diabetes. However, current guidelines do not include routine assessment of myocardial function. We investigated whether echocardiography provides incremental prognostic information in individuals with type 1 diabetes without known heart disease.

Methods: A prospective cohort of individuals with type 1 diabetes without known heart disease was recruited from the outpatient clinic. Follow-up was performed through Danish national registers. The association of echocardiography with major adverse cardiovascular events (MACE) and the incremental prognostic value when added to the clinical Steno T1D Risk Engine were examined.

Results: A total of 1093 individuals were included: median (interquartile range) age 50.2 (39.2-60.3) years and HbA 65 (56-74) mmol/mol; 53% men; and mean (SD) BMI 25.5 (3.9) kg/m and diabetes duration 25.8 (14.6) years. During 7.5 years of follow-up, 145 (13.3%) experienced MACE. Echocardiography significantly and independently predicted MACE: left ventricular ejection fraction (LVEF) <45% (n = 18) vs ≥45% (n = 1075), HR (95% CI) 3.93 (1.91, 8.08), p < 0.001; impaired global longitudinal strain (GLS), 1.65 (1.17, 2.34) (n = 263), p = 0.005; diastolic mitral early velocity (E)/early diastolic tissue Doppler velocity (e') <8 (n = 723) vs E/e' 8-12 (n = 285), 1.59 (1.04, 2.42), p = 0.031; and E/e' <8 vs E/e' ≥12 (n = 85), 2.30 (1.33, 3.97), p = 0.003. In individuals with preserved LVEF (n = 1075), estimates for impaired GLS were 1.49 (1.04, 2.15), p = 0.032; E/e' <8 vs E/e' 8-12, 1.61 (1.04, 2.49), p = 0.033; and E/e' <8 vs E/e' ≥12, 2.49 (1.41, 4.37), p = 0.001. Adding echocardiographic variables to the Steno T1D Risk Engine significantly improved risk prediction: Harrell's C statistic, 0.791 (0.757, 0.824) vs 0.780 (0.746, 0.815), p = 0.027; and net reclassification index, 52%, p < 0.001.

Conclusions/interpretation: In individuals with type 1 diabetes without known heart disease, echocardiography significantly improves risk prediction over and above guideline-recommended clinical risk factors alone and could have a role in clinical care.

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