Association of MTHFR C677T Polymorphism and Type 2 Diabetes Mellitus (T2DM) Susceptibility

Overview

Journal Mol Genet Genomic Med

Specialty Genetics

Date 2019 Oct 31

PMID 31663297

Citations 14

Authors

Yanzi Meng

Xiaoling Liu

Kai Ma

Lili Zhang

Mao Lu

Minsu Zhao

Min-Xin Guan

Guijun Qin

Affiliations

Soon will be listed here.

Abstract

Introduction: Methylenetetrahydrofolate reductase (MTHFR) is essential in mediating folate metabolism, and thus plays an important role in diabetes and diabetic complications. MTHFR C677T (rs1801133 C>T) polymorphism has been proposed to be linked with type 2 diabetes mellitus (T2DM) susceptibility. However, the conclusions are inconsistent. Therefore, we rechecked their linkage aiming to obtain a more reliable estimation by performing an updated meta-analysis.

Methods: We searched electronic databases PubMed, EMBASE, CNKI, and Wanfang to obtain studies updated to October 2019.

Results: After carefully screening, we finally incorporated 68 studies with 10,812 cases and 8,745 controls. The genotype frequency of C677T polymorphism was analyzed pooled to generate odds ratios (ORs) and 95% confidence intervals (CIs). Pooled results presented that MTHFR C677T polymorphism was significantly associated with T2DM under homozygous (OR = 1.64, 95% CI = 1.39-1.94), heterozygous (OR = 1.38, 95% CI = 1.20-1.59), recessive (OR = 1.41, 95% CI = 1.23-1.61), dominant (OR = 1.47, 95% CI = 1.27-1.70), and allele (OR = 1.37, 95% CI = 1.23-1.52) genetic models. Stratified analysis demonstrated that C677T genotype was associated with T2DM in Asian populations, but not Caucasian and African populations.

Conclusion: Our results indicated that MTHFR C677T polymorphism confers to T2DM, especially in Asian populations. Much more large-scale case-control studies are needed to strengthen such conclusion in the future.

Citing Articles

Association analysis of MTHFR (rs1801133 and rs1801131) gene polymorphism towards the development of type 2 diabetes mellitus in Dali area population from Yunnan Province, China.

Liu Y, Pu G, Yang C, Wang Y, Jin K, Wang S PeerJ. 2024; 12:e18334.

PMID: 39465169 PMC: 11512809. DOI: 10.7717/peerj.18334.

Methylenetetrahydrofolate reductase (MTHFR) polymorphisms in andrology-a narrative review.

Xie Z, Liu K, Zhang S, Gong Y, Wang Z, Lu P Transl Androl Urol. 2024; 13(8):1592-1601.

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The combined effect of MTHFR C677T and A1298C polymorphisms on the risk of digestive system cancer among a hypertensive population.

He Q, Wei Y, Zhu H, Liang Q, Chen P, Li S Discov Oncol. 2024; 15(1):97.

PMID: 38565713 PMC: 10987447. DOI: 10.1007/s12672-024-00960-y.

One-Carbon Metabolism Nutrients, Genetic Variation, and Diabetes Mellitus.

Zhu J, Saikia G, Zhang X, Shen X, Kahe K Diabetes Metab J. 2024; 48(2):170-183.

PMID: 38468500 PMC: 10995489. DOI: 10.4093/dmj.2023.0272.

Associations of CKIP-1 and LOX-1 polymorphisms with the risk of type 2 diabetes mellitus with hypertension among Chinese adults.

Xiong J, Zhang L, Chen G, Dong P, Tong J, Hua L Acta Diabetol. 2023; 61(1):43-52.

PMID: 37668684 DOI: 10.1007/s00592-023-02175-z.

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