Circulating Monocytes, Tissue Macrophages, and Malaria

Overview

Journal J Trop Med

Publisher Wiley

Specialty Tropical Medicine

Date 2019 Oct 31

PMID 31662766

Citations 14

Authors

Nida Ozarslan

Joshua F Robinson

Stephanie L Gaw

Affiliations

Soon will be listed here.

Abstract

Malaria is a significant cause of global morbidity and mortality. The parasite has a complex life cycle with mosquito, liver, and blood stages. The blood stages can preferentially affect organs such as the brain and placenta. In each of these stages and organs, the parasite will encounter monocytes and tissue-specific macrophages-key cell types in the innate immune response. Interactions between the parasite and monocytes/macrophages lead to several changes at both cellular and molecular levels, such as cytokine release and receptor expression. In this review, we summarize current knowledge on the relationship between malaria and blood intervillous monocytes and tissue-specific macrophages of the liver (Kupffer cells), central nervous system (microglia), and placenta (maternal intervillous monocytes and fetal Hofbauer cells). We describe their potential roles in modulating outcomes from infection and areas for future investigation.

Citing Articles

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Loglo A, Antwi P, Abass K, Osei-Mireku S, Amofa G, Ofori E PLoS Negl Trop Dis. 2025; 19(3):e0012871.

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Unveiling new perspectives about the onset of neurological and cognitive deficits in cerebral malaria: exploring cellular and neurochemical mechanisms.

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Plasmodium falciparum alters the trophoblastic barrier and stroma villi organization of human placental villi explants.

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Modulation of Heme-Induced Inflammation Using MicroRNA-Loaded Liposomes: Implications for Hemolytic Disorders Such as Malaria and Sickle Cell Disease.

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Curcumin as a Stabilizer of Macrophage Polarization during Infection.

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