Testicular Germ Cell Tumors: the Changing Role of the Pathologist

Overview

Journal Ann Transl Med

Publisher AME Publishing Company

Date 2019 Oct 29

PMID 31656783

Citations 4

Authors

Andrea Ronchi

Francesca Pagliuca

Renato Franco

Affiliations

Soon will be listed here.

Citing Articles

Gonadal Teratomas: A State-of-the-Art Review in Pathology.

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PMID: 39001474 PMC: 11240729. DOI: 10.3390/cancers16132412.

Testicular cancer in mice: interplay between stem cells and endocrine insults.

Kaushik A, Bhartiya D Stem Cell Res Ther. 2022; 13(1):243.

PMID: 35676718 PMC: 9175365. DOI: 10.1186/s13287-022-02784-5.

The utility of cfDNA in TGCT patient management: a systematic review.

Krasic J, Skara L, Bojanac A, Ulamec M, Jezek D, Kulis T Ther Adv Med Oncol. 2022; 14:17588359221090365.

PMID: 35656387 PMC: 9152191. DOI: 10.1177/17588359221090365.

Cisplatin Resistance in Testicular Germ Cell Tumors: Current Challenges from Various Perspectives.

Lobo J, Jeronimo C, Henrique R Cancers (Basel). 2020; 12(6).

PMID: 32560427 PMC: 7352163. DOI: 10.3390/cancers12061601.

References

Berney D, Algaba F, Amin M, Delahunt B, Comperat E, Epstein J . Handling and reporting of orchidectomy specimens with testicular cancer: areas of consensus and variation among 25 experts and 225 European pathologists. Histopathology. 2015; 67(3):313-24. PMC: 5026308. DOI: 10.1111/his.12657. View

Gallegos I, Valdevenito J, Miranda R, Fernandez C . Immunohistochemistry expression of P53, Ki67, CD30, and CD117 and presence of clinical metastasis at diagnosis of testicular seminoma. Appl Immunohistochem Mol Morphol. 2010; 19(2):147-52. DOI: 10.1097/PAI.0b013e3181f05a66. View

Johnson D, Gomez J, Ayala A . Anaplastic seminoma. J Urol. 1975; 114(1):80-2. DOI: 10.1016/s0022-5347(17)66948-9. View

Yilmaz A, Cheng T, Zhang J, Trpkov K . Testicular hilum and vascular invasion predict advanced clinical stage in nonseminomatous germ cell tumors. Mod Pathol. 2012; 26(4):579-86. DOI: 10.1038/modpathol.2012.189. View

Berney D, Lee A, Randle S, Jordan S, Shamash J, Oliver R . The frequency of intratubular embryonal carcinoma: implications for the pathogenesis of germ cell tumours. Histopathology. 2004; 45(2):155-61. DOI: 10.1111/j.1365-2559.2004.01915.x. View

Moch H, Cubilla A, Humphrey P, Reuter V, Ulbright T . The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. Eur Urol. 2016; 70(1):93-105. DOI: 10.1016/j.eururo.2016.02.029. View

Bonet A, Munoz-Delgado E, Vico F, Ruiz J, Chapado M . Analysis of clinical-pathologic variables, staging and prognostic groups, and therapeutic results of 106 germ-cell testicular tumors. Arch Esp Urol. 2012; 64(10):972-80. View

Dry S, Renshaw A . Extratesticular extension of germ cell tumors preferentially occurs at the hilum. Am J Clin Pathol. 1999; 111(4):534-8. DOI: 10.1093/ajcp/111.4.534. View

Valdevenito J, Gallegos I, Fernandez C, Acevedo C, Palma R . Correlation between primary tumor pathologic features and presence of clinical metastasis at diagnosis of testicular seminoma. Urology. 2007; 70(4):777-80. DOI: 10.1016/j.urology.2007.05.020. View

10.

Emerson R, Cheng L . Premalignancy of the testis and paratestis. Pathology. 2013; 45(3):264-72. DOI: 10.1097/PAT.0b013e32835f3e1a. View

11.

Sperger J, Chen X, Draper J, Antosiewicz J, Chon C, Jones S . Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci U S A. 2003; 100(23):13350-5. PMC: 263817. DOI: 10.1073/pnas.2235735100. View

12.

Lau S, Weiss L, Chu P . Association of intratubular seminoma and intratubular embryonal carcinoma with invasive testicular germ cell tumors. Am J Surg Pathol. 2007; 31(7):1045-9. DOI: 10.1097/PAS.0b013e31802b8712. View

13.

Farooq A, Jorda M, Whittington E, Kryvenko O, Braunhut B, Pavan N . Rete Testis Invasion Is Consistent With Pathologic Stage T1 in Germ Cell Tumors. Am J Clin Pathol. 2018; 151(5):479-485. DOI: 10.1093/ajcp/aqy168. View

14.

Lobo J, Laura Costa A, Vilela-Salgueiro B, Rodrigues A, Guimaraes R, Cantante M . Testicular germ cell tumors: revisiting a series in light of the new WHO classification and AJCC staging systems, focusing on challenges for pathologists. Hum Pathol. 2018; 82:113-124. DOI: 10.1016/j.humpath.2018.07.016. View

15.

Berney D, Looijenga L, Idrees M, Oosterhuis J, Rajpert-De Meyts E, Ulbright T . Germ cell neoplasia in situ (GCNIS): evolution of the current nomenclature for testicular pre-invasive germ cell malignancy. Histopathology. 2016; 69(1):7-10. DOI: 10.1111/his.12958. View

16.

Milose J, Filson C, Weizer A, Hafez K, Montgomery J . Role of biochemical markers in testicular cancer: diagnosis, staging, and surveillance. Open Access J Urol. 2013; 4:1-8. PMC: 3818947. DOI: 10.2147/OAJU.S15063. View

17.

Oosterhuis J, Kersemaekers A, Jacobsen G, Timmer A, Steyerberg E, Molier M . Morphology of testicular parenchyma adjacent to germ cell tumours. An interim report. APMIS. 2003; 111(1):32-40; discussion 41-2. DOI: 10.1034/j.1600-0463.2003.11101061.x. View

18.

David S, Andras F, Endre K, Balint K, Arpad K, Csaba P . More Cases of Benign Testicular Teratomas are Detected in Adults than in Children. A Clinicopathological Study of 543 Testicular Germ Cell Tumor Cases. Pathol Oncol Res. 2016; 23(3):513-517. DOI: 10.1007/s12253-016-0120-3. View

19.

Giannoulatou E, Maher G, Ding Z, Gillis A, Dorssers L, Hoischen A . Whole-genome sequencing of spermatocytic tumors provides insights into the mutational processes operating in the male germline. PLoS One. 2017; 12(5):e0178169. PMC: 5439955. DOI: 10.1371/journal.pone.0178169. View

20.

Som A, Zhu R, Guo C, Efstathiou E, Xiao L, Pisters L . Recurrent seminomas: clinical features and biologic implications. Urol Oncol. 2010; 30(4):494-501. PMC: 3856193. DOI: 10.1016/j.urolonc.2010.05.011. View