Handling and Reporting of Orchidectomy Specimens with Testicular Cancer: Areas of Consensus and Variation Among 25 Experts and 225 European Pathologists

Overview

Journal Histopathology

Specialties Anatomy & Histology
Pathology

Date 2015 Jan 27

PMID 25619976

Citations 10

Authors

Daniel M Berney

Ferran Algaba

Mahul Amin

Brett Delahunt

Eva Comperat

Jonathan I Epstein

Peter Humphrey

Mohammed Idrees

Antonio Lopez-Beltran

Cristina Magi-Galluzzi

Gregor Mikuz

Rodolfo Montironi

Esther Oliva

John Srigley

Victor E Reuter

Kiril Trpkov

Thomas M Ulbright

Murali Varma

Clare Verrill

Robert H Young

Ming Zhou

Lars Egevad

Affiliations

Soon will be listed here.

Abstract

Aims: The handling and reporting of testicular tumours is difficult due to their rarity.

Methods And Results: A survey developed by the European Network of Uro-Pathology (ENUP) and sent to its members and experts to assess the evaluation of testicular germ cell tumours. Twenty-five experts and 225 ENUP members replied. Areas of disagreement included immaturity in teratomas, reported by 32% of experts but 68% of ENUP. Although the presence of rete testis invasion was reported widely, the distinction between pagetoid and stromal invasion was made by 96% of experts but only 63% of ENUP. Immunohistochemistry was used in more than 50% of cases by 68% of ENUP and 12% of experts. Staging revealed the greatest areas of disagreement. Invasion of the tunica vaginalis without vascular invasion was interpreted as T1 by 52% of experts and 67% of ENUP, but T2 by the remainder. Tumour invading the hilar adipose tissue adjacent to the epididymis without vascular invasion was interpreted as T1: 40% of experts, 43% of ENUP; T2: 36% of experts, 30% of ENUP; and T3: 24% of experts, 27% of ENUP.

Conclusions: There is remarkable consensus in many areas of testicular pathology. Significant areas of disagreement included staging and reporting of histological types, both of which have the potential to impact on therapy.

Citing Articles

Multifocality in Testicular Cancer: Clinicopathological Correlations and Prognostic Implications.

Bumbasirevic U, Petrovic M, Zekovic M, Coric V, Milojevic B, Lisicic N Life (Basel). 2024; 14(2).

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Treatment options in stage I seminoma.

Bumbasirevic U, Zivkovic M, Petrovic M, Coric V, Lisicic N, Bojanic N Oncol Res. 2023; 30(3):117-128.

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Biomarkers of disease recurrence in stage I testicular germ cell tumours.

Lesko P, Chovanec M, Mego M Nat Rev Urol. 2022; 19(11):637-658.

PMID: 36028719 DOI: 10.1038/s41585-022-00624-y.

Associations of serum levels of microRNA-371a-3p (M371) with risk factors for progression in nonseminomatous testicular germ cell tumours clinical stage 1.

Dieckmann K, Dumlupinar C, Radtke A, Matthies C, Pichler R, Paffenholz P World J Urol. 2021; 40(2):317-326.

PMID: 34775512 PMC: 8921024. DOI: 10.1007/s00345-021-03876-2.

Testicular Germ-Cell Tumors with Spermatic Cord Involvement: A Retrospective International Multi-Institutional Experience.

Pena M, Canete-Portillo S, Amin A, Aron M, Colombo P, Cox R Mod Pathol. 2021; 35(2):249-255.

PMID: 34504308 DOI: 10.1038/s41379-021-00912-9.

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