Potential for BioXmark Liquid Fiducial Marker to Improve Identification of Superficial Component of Canine Oral Tumors for Computer-based Radiation Therapy Planning

Overview

Journal Can Vet J

Specialty Veterinary Medicine

Date 2019 Oct 11

PMID 31597992

Citations 1

Authors

Benoit Clerc-Renaud

Mary-Keara Boss

Lynn R Griffin

Susan M LaRue

Del Leary

Affiliations

Soon will be listed here.

Abstract

The objective of this study was to evaluate a novel liquid fiducial marker, BioXmark, to improve identification of the superficial component of oral tumors in dogs with computed tomography imaging. Liquid fiducial marker was injected in 6 patients at the visible and palpable extent of each tumor. Gross tumor volumes with and without BioXmark were compared in terms of volume and conformity using a Paddick conformity index, Dice similarity coefficient, and gross tumor volumes mismatch analysis. All patients showed an increase in gross tumor volumes defined by BioXmark compared with the conventionally identified post-contrast gross tumor volumes contours. Volumetric conformity and gross tumor volumes mismatch analysis of the superficial component of gross tumor volumes resulted in a median conformity index of 0.61 and median Dice similarity coefficient of 0.76. The superficial gross tumor volumes showed a median increase of 47% when BioXmark was used. This study demonstrated a potential utility to combining liquid fiducial markers to post-contrast computed tomography images for improved oral tumor localization and gross tumor volumes contouring for radiation therapy planning.

Citing Articles

BioXmark® liquid fiducials to enable radiotherapy tumor boosting in rectal cancer, a feasibility trial.

Opbroek T, Willems Y, Verhaegen F, de Ridder R, Hoge C, Melenhorst J Clin Transl Radiat Oncol. 2022; 38:90-95.

PMID: 36407490 PMC: 9668658. DOI: 10.1016/j.ctro.2022.10.013.

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