Helper and Suppressor T Lymphocyte Function in Severe Alcoholic Liver Disease

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1985 Apr 1

PMID 3159525

Citations 4

Authors

U McKeever

C OMahony

C A Whelan

D G Weir

C Feighery

Affiliations

Soon will be listed here.

Abstract

The immune regulatory T cell status of patients with severe alcoholic liver disease (ALD) was investigated. Using monoclonal antibodies to identify lymphocyte subsets in 22 patients, a significant decrease in the percentage of T suppressor/cytotoxic cells (P less than 0.01) and increase in the percentage T helper/inducer population (P less than 0.05) was observed when the results were compared with 20 normal controls. However, when absolute numbers of these lymphocyte subsets were calculated the patient group did not differ significantly from the controls. Further studies revealed T immunoregulatory cell function to be normal. Concanavalin A induced suppressor cells resulted in equivalent inhibition of autologous cell mitogen responsiveness in the patient and control groups. In addition, purified patient T lymphocytes were demonstrated to provide normal help to and manifest normal suppression of IgG, IgA and IgM synthesis by allogeneic B cells. When spontaneous immunoglobulin synthesis by circulating mononuclear cells was investigated, a significant increase in IgA synthesis was found in the ALD patients (P less than 0.05). These results suggest that T cell immunoregulation is normal in patients with ALD and a defect in this system is not responsible for the increased synthesis of immunoglobulin observed in ALD.

Citing Articles

Decreased proliferative activity associated with activation markers in patients with alcoholic liver cirrhosis.

Deviere J, Denys C, Schandene L, Romasco F, Adler M, Wybran J Clin Exp Immunol. 1988; 72(3):377-82.

PMID: 3262458 PMC: 1541554.

Defective suppression in the autologous mixed lymphocyte reaction in patients with Crohn's disease.

Kelleher D, Murphy A, Whelan C, Feighery C, Weir D, Keeling P Gut. 1989; 30(6):839-44.

PMID: 2526783 PMC: 1434121. DOI: 10.1136/gut.30.6.839.

High interleukin-6 serum levels and increased production by leucocytes in alcoholic liver cirrhosis. Correlation with IgA serum levels and lymphokines production.

Deviere J, Content J, Denys C, Vandenbussche P, Schandene L, Wybran J Clin Exp Immunol. 1989; 77(2):221-5.

PMID: 2505958 PMC: 1541981.

T-lymphocyte activation pathways in alcoholic liver disease.

Spinozzi F, Bertotto A, Rondoni F, Gerli R, Scalise F, Grignani F Immunology. 1991; 73(2):140-6.

PMID: 1676985 PMC: 1384456.

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