High Interleukin-6 Serum Levels and Increased Production by Leucocytes in Alcoholic Liver Cirrhosis. Correlation with IgA Serum Levels and Lymphokines Production

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1989 Aug 1

PMID 2505958

Citations 49

Authors

J Deviere

J Content

C Denys

P Vandenbussche

L Schandene

J Wybran

E Dupont

Affiliations

Soon will be listed here.

Abstract

Hypergammaglobulinaemia and enhanced serum IgA levels are common in alcoholic liver cirrhosis. Interleukin-6 (IL-6), which is identical to B cell differentiation factor BSF2 and is implicated in various autoimmune diseases, has been studied in patients with alcoholic liver cirrhosis. Increased serum levels and spontaneous or induced production of IL-6 by peripheral blood monoclonal cells have been found. IL-6 production correlates closely with IgA serum levels and negatively with impaired interleukin-2 and interferon gamma production. This abnormality could be related to overproduction of immunoglobulins and immune disturbances observed in this disease.

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