Evolutionary Simulations of -linked Suppression Gene Drives

Overview

Journal Proc Biol Sci

Specialty Biology

Date 2019 Oct 10

PMID 31594512

Citations 6

Authors

Luke Holman

Affiliations

Soon will be listed here.

Abstract

Synthetic gene drives may soon be used to suppress or eliminate populations of disease vectors, pathogens, invasive species, and agricultural pests. Recent proposals have focused on using -linked gene drives to control species with sex determination, which include Lepidopteran pests, parasitic trematodes, and cane toads. These proposals include -linked '-shredders', which would suppress populations by cleaving the chromosome and causing females to produce only sons, as well as -linked female-sterilizing gene drives. Here, I use eco-evolutionary simulations to evaluate the potential of some proposed -linked gene drives, and to produce recommendations regarding their design and use. The simulations show that -shredders are likely to be highly effective at eradicating populations provided that resistance to -shredding cannot evolve. However, -shredder alleles can invade populations from very low frequencies, making it difficult to eliminate specific populations while leaving nearby populations untouched; this issue may restrict their possible uses.

Citing Articles

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Slow and steady wins the race: Spatial and stochastic processes and the failure of suppression gene drives.

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Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post-market environmental monitoring of genetically modified insects containing engineered gene drives.

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