PHA-induced Soluble Factor(s) Can Activate B-cells from Patients with Chronic Lymphatic Leukaemia

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1979 Sep 1

PMID 315847

Citations 5

Authors

K H Robert

Affiliations

Soon will be listed here.

Abstract

Blood lymphocytes from eight patients with chronic lymphatic leukaemia (CLL) were stimulated by phytohaemagglutinin (PHA). The effect was defined as a pronounced increase of 3H-thymidine incorporation, and a concomitant blast transformation of a large portion of surface Ig-positive, E-rosette-forming (E-RFC) negative cells. E-RFC depletion reduced these effects to nearly background levels, and the pooled data strongly suggest that malignant B-lymphocytes in CLL are capable of responding to a PHA-induced T cell factor. A possible use for this factor in characterizing different subpopulations of CLL cells is discussed.

Citing Articles

Mitogenic stimulation of malignant B cells. Chronic lymphocytic leukaemia: relationship between stimulation and surface phenotype.

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The roles of leukaemic and residual normal cells in the proliferative response of chronic lymphocytic leukaemic lymphocytes to mitogens.

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Stimulation of chronic lymphatic leukaemia cells by pokeweed mitogen after treatment with neuraminidase-galactose oxidase.

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Stimulation of T lymphocytes by protein A from Staphylococcus aureus in B-derived chronic lymphocytic leukaemia.

Guglielmi P, PreudHomme J Clin Exp Immunol. 1980; 41(1):136-40.

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Polyclonal human T lymphocyte activation results in the secondary functional activation of the human B lymphocyte.

Bird A, Hammarstrom L, Smith C, Britton S Clin Exp Immunol. 1981; 43(1):165-73.

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References

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