A Facile and Regioselective Multicomponent Synthesis of Chiral Aryl-1,2-mercaptoamines in Water Followed by Monoamine Oxidase (MAO-N) Enzymatic Resolution

A facile microwave assisted three-component protocol allows the synthesis of chiral aryl-1,2-mercaptoamines in water in a few minutes with high yields, bypassing the use of toxic aziridine intermediates. The chiral 1,2-mercaptoamines were then deracemized through enzymatic resolution of the racemates using monoamine oxidase (MAO-N) biocatalysts.