Astroglia in Alzheimer's Disease

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2019 Oct 5

PMID 31583592

Citations 45

Authors

Alexei Verkhratsky

Vladimir Parpura

Jose Julio Rodriguez-Arellano

Robert Zorec

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease is the most common cause of dementia. Cellular changes in the brains of the patients suffering from Alzheimer's disease occur well in advance of the clinical symptoms. At the cellular level, the most dramatic is a demise of neurones. As astroglial cells carry out homeostatic functions of the brain, it is certain that these cells are at least in part a cause of Alzheimer's disease. Historically, Alois Alzheimer himself has recognised this at the dawn of the disease description. However, the role of astroglia in this disease has been understudied. In this chapter, we summarise the various aspects of glial contribution to this disease and outline the potential of using these cells in prevention (exercise and environmental enrichment) and intervention of this devastating disease.

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References

Garwood C, Faizullabhoy A, Wharton S, Ince P, Heath P, Shaw P . Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain. Neuropathol Appl Neurobiol. 2013; 39(7):788-99. DOI: 10.1111/nan.12033. View

Dodart J, Mathis C, Saura J, Bales K, Paul S, Ungerer A . Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice. Neurobiol Dis. 2000; 7(2):71-85. DOI: 10.1006/nbdi.1999.0278. View

Ishihara T, Higuchi M, Zhang B, Yoshiyama Y, Hong M, Trojanowski J . Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments. J Neurosci. 2001; 21(16):6026-35. PMC: 6763173. View

Zorec R, Parpura V, Vardjan N, Verkhratsky A . Astrocytic face of Alzheimer's disease. Behav Brain Res. 2016; 322(Pt B):250-257. DOI: 10.1016/j.bbr.2016.05.021. View

Verkhratsky A, Nedergaard M . Astroglial cradle in the life of the synapse. Philos Trans R Soc Lond B Biol Sci. 2014; 369(1654):20130595. PMC: 4173281. DOI: 10.1098/rstb.2013.0595. View

Nagele R, DAndrea M, Lee H, Venkataraman V, Wang H . Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains. Brain Res. 2003; 971(2):197-209. DOI: 10.1016/s0006-8993(03)02361-8. View

Grosche J, Matyash V, Moller T, Verkhratsky A, Reichenbach A, Kettenmann H . Microdomains for neuron-glia interaction: parallel fiber signaling to Bergmann glial cells. Nat Neurosci. 1999; 2(2):139-43. DOI: 10.1038/5692. View

Roth M, Tomlinson B, Blessed G . The relationship between quantitative measures of dementia and of degenerative changes in the cerebral grey matter of elderly subjects. Proc R Soc Med. 1967; 60(3):254-60. PMC: 1901649. View

Janus C, Pearson J, McLaurin J, Mathews P, Jiang Y, Schmidt S . A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 2001; 408(6815):979-82. DOI: 10.1038/35050110. View

10.

Arendash G, Lewis J, Leighty R, McGowan E, Cracchiolo J, Hutton M . Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. Brain Res. 2004; 1012(1-2):29-41. DOI: 10.1016/j.brainres.2004.02.081. View

11.

Alberdi E, Wyssenbach A, Alberdi M, Sanchez-Gomez M, Cavaliere F, Rodriguez J . Ca(2+) -dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease. Aging Cell. 2013; 12(2):292-302. DOI: 10.1111/acel.12054. View

12.

Orre M, Kamphuis W, Osborn L, Jansen A, Kooijman L, Bossers K . Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction. Neurobiol Aging. 2014; 35(12):2746-2760. DOI: 10.1016/j.neurobiolaging.2014.06.004. View

13.

Rossi D, Volterra A . Astrocytic dysfunction: insights on the role in neurodegeneration. Brain Res Bull. 2009; 80(4-5):224-32. DOI: 10.1016/j.brainresbull.2009.07.012. View

14.

Verkhratsky A, Trebak M, Perocchi F, Khananshvili D, Sekler I . Crosslink between calcium and sodium signalling. Exp Physiol. 2017; 103(2):157-169. PMC: 6813793. DOI: 10.1113/EP086534. View

15.

Knight R, Verkhratsky A . Neurodegenerative diseases: failures in brain connectivity?. Cell Death Differ. 2010; 17(7):1069-70. DOI: 10.1038/cdd.2010.23. View

16.

Ovsepian S, OLeary V, Zaborszky L, Ntziachristos V, Dolly J . Amyloid Plaques of Alzheimer's Disease as Hotspots of Glutamatergic Activity. Neuroscientist. 2018; 25(4):288-297. PMC: 6348130. DOI: 10.1177/1073858418791128. View

17.

Bell R, Zlokovic B . Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol. 2009; 118(1):103-13. PMC: 2853006. DOI: 10.1007/s00401-009-0522-3. View

18.

Weinshilboum R . Serum dopamine beta-hydroxylase. Pharmacol Rev. 1978; 30(2):133-66. View

19.

Duyckaerts C, Delatour B, Potier M . Classification and basic pathology of Alzheimer disease. Acta Neuropathol. 2009; 118(1):5-36. DOI: 10.1007/s00401-009-0532-1. View

20.

Kim K, Lee S, Kegelman T, Su Z, Das S, Dash R . Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics. J Cell Physiol. 2011; 226(10):2484-93. PMC: 3130100. DOI: 10.1002/jcp.22609. View