Disposable Microfluidic Sensor Based on Nanocellulose for Glucose Detection

Overview

Journal Glob Chall

Date 2019 Oct 1

PMID 31565363

Citations 5

Authors

Khan Mohammad Ahsan Uddin

Ville Jokinen

Farzin Jahangiri

Sami Franssila

Orlando J Rojas

Sampo Tuukkanen

Affiliations

Soon will be listed here.

Abstract

Point-of-care devices that are inexpensive, disposable, and environmentally friendly are becoming increasingly predominant in the field of biosensing and biodiagnostics. Here, microfluidics is a suitable option to endow portability and minimal reagent and material consumption. Nanocellulose is introduced to manufacture microfluidic channels and as a storage and immobilization compartment of glucose oxidase. Improved enzymatic activity retention is demonstrated in a simple and disposable point-of-care diagnostic unit that is able to detect glucose from fluid matrices at 0.1 × 10 m concentration and in less than 10 min. It is concluded that the patterning and fluidic technologies that are possible with nanocellulose enable easily scalable multianalyte designs.

Citing Articles

Nanocellulosics in Transient Technology.

Iroegbu A, Sinha Ray S ACS Omega. 2023; 7(51):47547-47566.

PMID: 36591168 PMC: 9798511. DOI: 10.1021/acsomega.2c05848.

The Frontiers of Functionalized Nanocellulose-Based Composites and Their Application as Chemical Sensors.

Norrrahim M, Knight V, Nurazzi N, Jenol M, Misenan M, Janudin N Polymers (Basel). 2022; 14(20).

PMID: 36298039 PMC: 9608972. DOI: 10.3390/polym14204461.

Detection of Human Neutrophil Elastase by Fluorescent Peptide Sensors Conjugated to TEMPO-Oxidized Nanofibrillated Cellulose.

Mackin R, Fontenot K, Edwards J, Prevost N, Jordan J, Easson M Int J Mol Sci. 2022; 23(6).

PMID: 35328520 PMC: 8952216. DOI: 10.3390/ijms23063101.

Disposable Microfluidic Sensor Based on Nanocellulose for Glucose Detection.

Uddin K, Jokinen V, Jahangiri F, Franssila S, Rojas O, Tuukkanen S Glob Chall. 2019; 3(2):1800079.

PMID: 31565363 PMC: 6607311. DOI: 10.1002/gch2.201800079.

Cellulose Nano-Films as Bio-Interfaces.

Raghuwanshi V, Garnier G Front Chem. 2019; 7:535.

PMID: 31417896 PMC: 6682661. DOI: 10.3389/fchem.2019.00535.

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