Are Conditioned Open Placebos Feasible As an Adjunctive Treatment to Opioids? Results from a Single-Group Dose-Extender Pilot Study with Acute Pain Patients

Overview

Journal Psychother Psychosom

Publisher Karger

Specialties Pharmacology
Psychiatry

Date 2019 Sep 30

PMID 31563914

Citations 8

Authors

Michael H Bernstein

Molly Magill

Arnold-Peter Weiss

Ted J Kaptchuk

Charlotte Blease

Irving Kirsch

Josiah D Rich

Sara J Becker

Steven Mach

Francesca L Beaudoin

Affiliations

Soon will be listed here.

Citing Articles

Boosting open-label placebo effects in acute induced pain in healthy adults (BOLPAP-study): study protocol of a randomized controlled trial.

de Leeuw M, Laager M, Gaab J, Ruppen W, Schneider T Front Med (Lausanne). 2024; 11:1238878.

PMID: 38420356 PMC: 10900763. DOI: 10.3389/fmed.2024.1238878.

Effectiveness of Conditioned Open-label Placebo With Methadone in Treatment of Opioid Use Disorder: A Randomized Clinical Trial.

Belcher A, Cole T, Massey E, Billing A, Wagner M, Wooten W JAMA Netw Open. 2023; 6(4):e237099.

PMID: 37043203 PMC: 10099063. DOI: 10.1001/jamanetworkopen.2023.7099.

"Let's see what happens:"-Women's experiences of open-label placebo treatment for menopausal hot flushes in a randomized controlled trial.

Pan Y, Frank M, Kaptchuk T, Nestoriuc Y PLoS One. 2022; 17(11):e0276499.

PMID: 36331921 PMC: 9635716. DOI: 10.1371/journal.pone.0276499.

Experiences of Patients Taking Conditioned Open-Label Placebos for Reduction of Postoperative Pain and Opioid Exposure After Spine Surgery.

Hruschak V, Flowers K, Patton M, Merchantz V, Schwartz E, Edwards R Int J Behav Med. 2022; 30(4):509-521.

PMID: 35915346 DOI: 10.1007/s12529-022-10114-5.

How orthopedic surgeons view open label placebo pills: Ethical and effective, but opposed to personal use.

Bernstein M, Rosenfield M, Fuchs N, Magill M, Blease C, Beaudoin F J Psychosom Res. 2021; 151:110638.

PMID: 34644614 PMC: 8633179. DOI: 10.1016/j.jpsychores.2021.110638.

References

Kaptchuk T . Open-Label Placebo: Reflections on a Research Agenda. Perspect Biol Med. 2018; 61(3):311-334. DOI: 10.1353/pbm.2018.0045. View

Blease C, Bernstein M, Locher C . Open-label placebo clinical trials: is it the rationale, the interaction or the pill?. BMJ Evid Based Med. 2019; 25(5):159-165. PMC: 6930978. DOI: 10.1136/bmjebm-2019-111209. View

PARK L, Covi L . NONBLIND PLACEBO TRIAL: AN EXPLORATION OF NEUROTIC PATIENTS' RESPONSES TO PLACEBO WHEN ITS INERT CONTENT IS DISCLOSED. Arch Gen Psychiatry. 1965; 12:36-45. View

Davis C, Lieberman A, Hernandez-Delgado H, Suba C . Laws limiting the prescribing or dispensing of opioids for acute pain in the United States: A national systematic legal review. Drug Alcohol Depend. 2018; 194:166-172. DOI: 10.1016/j.drugalcdep.2018.09.022. View

Fava G, Guidi J, Rafanelli C, Rickels K . The Clinical Inadequacy of the Placebo Model and the Development of an Alternative Conceptual Framework. Psychother Psychosom. 2017; 86(6):332-340. DOI: 10.1159/000480038. View