Harnessing the Placebo Effect: a Promising Method for Curbing the Opioid Crisis?

Overview

Journal Addiction

Specialty Psychiatry

Date 2018 Jul 11

PMID 29989293

Citations 4

Authors

Michael H Bernstein

Molly Magill

Francesca L Beaudoin

Sara J Becker

Josiah D Rich

Affiliations

Soon will be listed here.

Citing Articles

Editorial: Placebo Effect in Pain and Pain Treatment.

Bernstein M, Blease C, Vase L Front Pain Res (Lausanne). 2022; 3():884055.

PMID: 35425939 PMC: 9001887. DOI: 10.3389/fpain.2022.884055.

Treating Pain With Open-Label Placebos: A Qualitative Study With Post-Surgical Pain Patients.

Bernstein M, Fuchs N, Rosenfield M, Weiss A, Blease C, Locher C J Pain. 2021; 22(11):1518-1529.

PMID: 34004348 PMC: 8578133. DOI: 10.1016/j.jpain.2021.05.001.

Are Conditioned Open Placebos Feasible as an Adjunctive Treatment to Opioids? Results from a Single-Group Dose-Extender Pilot Study with Acute Pain Patients.

Bernstein M, Magill M, Weiss A, Kaptchuk T, Blease C, Kirsch I Psychother Psychosom. 2019; 88(6):380-382.

PMID: 31563914 PMC: 6868304. DOI: 10.1159/000503038.

Open-label placebo clinical trials: is it the rationale, the interaction or the pill?.

Blease C, Bernstein M, Locher C BMJ Evid Based Med. 2019; 25(5):159-165.

PMID: 31243047 PMC: 6930978. DOI: 10.1136/bmjebm-2019-111209.

References

Benedetti F, Mayberg H, Wager T, Stohler C, Zubieta J . Neurobiological mechanisms of the placebo effect. J Neurosci. 2005; 25(45):10390-402. PMC: 6725834. DOI: 10.1523/JNEUROSCI.3458-05.2005. View

Carvalho C, Caetano J, Cunha L, Rebouta P, Kaptchuk T, Kirsch I . Open-label placebo treatment in chronic low back pain: a randomized controlled trial. Pain. 2016; 157(12):2766-2772. PMC: 5113234. DOI: 10.1097/j.pain.0000000000000700. View

BEECHER H . The powerful placebo. J Am Med Assoc. 1955; 159(17):1602-6. DOI: 10.1001/jama.1955.02960340022006. View

Kaptchuk T, Friedlander E, Kelley J, Sanchez M, Kokkotou E, Singer J . Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS One. 2011; 5(12):e15591. PMC: 3008733. DOI: 10.1371/journal.pone.0015591. View

Leung P, Macdonald E, Stanbrook M, Dhalla I, Juurlink D . A 1980 Letter on the Risk of Opioid Addiction. N Engl J Med. 2017; 376(22):2194-2195. DOI: 10.1056/NEJMc1700150. View

Kaptchuk T, Miller F . Placebo Effects in Medicine. N Engl J Med. 2015; 373(1):8-9. DOI: 10.1056/NEJMp1504023. View

Volkow N, McLellan A . Opioid Abuse in Chronic Pain--Misconceptions and Mitigation Strategies. N Engl J Med. 2016; 374(13):1253-63. DOI: 10.1056/NEJMra1507771. View

Collins F, Koroshetz W, Volkow N . Helping to End Addiction Over the Long-term: The Research Plan for the NIH HEAL Initiative. JAMA. 2018; 320(2):129-130. PMC: 6688196. DOI: 10.1001/jama.2018.8826. View

Porter J, Jick H . Addiction rare in patients treated with narcotics. N Engl J Med. 1980; 302(2):123. DOI: 10.1056/nejm198001103020221. View

10.

Charlesworth J, Petkovic G, Kelley J, Hunter M, Onakpoya I, Roberts N . Effects of placebos without deception compared with no treatment: A systematic review and meta-analysis. J Evid Based Med. 2017; 10(2):97-107. DOI: 10.1111/jebm.12251. View

11.

Locher C, Frey Nascimento A, Kirsch I, Kossowsky J, Meyer A, Gaab J . Is the rationale more important than deception? A randomized controlled trial of open-label placebo analgesia. Pain. 2017; 158(12):2320-2328. DOI: 10.1097/j.pain.0000000000001012. View

12.

PARK L, Covi L . NONBLIND PLACEBO TRIAL: AN EXPLORATION OF NEUROTIC PATIENTS' RESPONSES TO PLACEBO WHEN ITS INERT CONTENT IS DISCLOSED. Arch Gen Psychiatry. 1965; 12:36-45. View

13.

Finniss D, Kaptchuk T, Miller F, Benedetti F . Biological, clinical, and ethical advances of placebo effects. Lancet. 2010; 375(9715):686-95. PMC: 2832199. DOI: 10.1016/S0140-6736(09)61706-2. View

14.

Volkow N, Collins F . The Role of Science in Addressing the Opioid Crisis. N Engl J Med. 2017; 377(4):391-394. DOI: 10.1056/NEJMsr1706626. View

15.

Forsberg J, Martinussen M, Flaten M . The Placebo Analgesic Effect in Healthy Individuals and Patients: A Meta-Analysis. Psychosom Med. 2016; 79(4):388-394. DOI: 10.1097/PSY.0000000000000432. View