Simultaneous Optimization of Ultrasound-Assisted Extraction for Flavonoids and Antioxidant Activity of Using Response Surface Methodology (RSM)

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2019 Sep 27

PMID 31554203

Citations 18

Authors

Lei Zhang

Yuhuan Jiang

Xuening Pang

Puyue Hua

Xiang Gao

Qun Li

Zichao Li

Affiliations

Soon will be listed here.

Abstract

Koidzumi (), as a Japanese edible herbal plant, enjoys a variety of biological activities due to the presence of numerous active compounds, especially flavonoids. This study aims for the optimization of ultrasound-assisted extraction (UAE) for flavonoids in and their antioxidant activity by using the response surface methodology (RSM). Single-factor experiments and a four-factor three-level Box-Behnken design (BBD) were performed to explore the effects of the following parameters on flavonoid extraction and antioxidant activity evaluation: ultrasonic temperature (X), ultrasonic time (X), ethanol concentration (X) and liquid-solid ratio (X). The optimum conditions of the combination of total flavonoid content (TFC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity (DPPH-RSC) and ferric-reducing antioxidant power (FRAP) were as follows: X = 80 °C, X = 4 min, X = 78%, X = 35 mL/g, respectively. The experimental results provide a theoretical basis for the extensive utilization of and flavonoids extraction from as a potential source of antioxidants.

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