Response Surface Modeling and Optimization of Ultrasound-assisted Extraction of Three Flavonoids from Tartary Buckwheat (Fagopyrum Tataricum)

Overview

Journal Pharmacogn Mag

Publisher Sage Publications

Date 2013 Aug 10

PMID 23930003

Citations 9

Authors

Lian-Xin Peng

Liang Zou

Jiang-Lin Zhao

Da-Bing Xiang

Peng Zhu

Gang Zhao

Affiliations

Soon will be listed here.

Abstract

Background: Buckwheat (Fagopyrum spp., Polygonaceae) is a widely planted food crop. Flavonoids, including quercetin, rutin, and kaempferol, are the main bioactive components in tartary buckwheat (Fagopyrum tataricum (L.) Gaertn). From the nutriological and pharmacological perspectives, flavonoids have great value in controlling blood glucose and blood pressure levels, and they also have antioxidant properties.

Objective: To optimize the conditions for extraction of quercetin, rutin, and kaempferol from F. tataricum.

Materials And Methods: A combination of ultrasound-assisted extraction (UAE) and response surface methodology (RSM) was used for flavonoid extraction and yield assessment. The RSM was based on a three-level, three-variable Box-Behnken design.

Results: Flavonoids were optimally extracted from F. tataricum by using 72% methanol, at 60°C, for 21 minutes. Under these conditions, the obtained extraction yield of the total flavonoids was 3.94%.

Conclusion: The results indicated that the UAE method was effective for extraction of flavonoids from tartary buckwheat.

Citing Articles

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Optimization of Ultrasonicated Kaempferol Extraction from Using a Box-Behnken Design and Its Densitometric Validation.

Altemimi A, Mohammed M, Yi-Chen L, Watson D, Lakhssassi N, Cacciola F Foods. 2020; 9(10).

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Simultaneous Optimization of Ultrasound-Assisted Extraction for Flavonoids and Antioxidant Activity of Using Response Surface Methodology (RSM).

Zhang L, Jiang Y, Pang X, Hua P, Gao X, Li Q Molecules. 2019; 24(19).

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References

Ryad A, Lakhdar K, Majda K, Samia A, Mark A, Corinne A . Optimization of the culture medium composition to improve the production of hyoscyamine in elicited Datura stramonium L. hairy roots using the Response Surface Methodology (RSM). Int J Mol Sci. 2010; 11(11):4726-40. PMC: 3000111. DOI: 10.3390/ijms11114726. View

Mehrnoush A, Mustafa S, Islam Sarker M, Yazid A . Optimization of the conditions for extraction of serine protease from kesinai plant (Streblus asper) leaves using response surface methodology. Molecules. 2011; 16(11):9245-60. PMC: 6264442. DOI: 10.3390/molecules16119245. View

Kim S, Cui C, Kang I, Kim S, Ham S . Cytotoxic effect of buckwheat (Fagopyrum esculentum Moench) hull against cancer cells. J Med Food. 2007; 10(2):232-8. DOI: 10.1089/jmf.2006.1089. View

Yao Y, Shan F, Bian J, Chen F, Wang M, Ren G . D-chiro-inositol-enriched tartary buckwheat bran extract lowers the blood glucose level in KK-Ay mice. J Agric Food Chem. 2008; 56(21):10027-31. DOI: 10.1021/jf801879m. View

Zhao L, He Y, Deng X, Yang G, Li W, Liang J . Response surface modeling and optimization of accelerated solvent extraction of four lignans from fructus schisandrae. Molecules. 2012; 17(4):3618-29. PMC: 6268468. DOI: 10.3390/molecules17043618. View

Zhao G, Zou L, Wang Z, Hu H, Hu Y, Peng L . Pharmacokinetic profile of total quercetin after single oral dose of tartary buckwheat extracts in rats. J Agric Food Chem. 2011; 59(9):4435-41. DOI: 10.1021/jf1049529. View

Liu W, Yu Y, Yang R, Wan C, Xu B, Cao S . Optimization of total flavonoid compound extraction from Gynura medica leaf using response surface methodology and chemical composition analysis. Int J Mol Sci. 2010; 11(11):4750-63. PMC: 3000113. DOI: 10.3390/ijms11114750. View

Zhao L, Liang J, Li W, Cheng K, Xia X, Deng X . The use of response surface methodology to optimize the ultrasound-assisted extraction of five anthraquinones from Rheum palmatum L. Molecules. 2011; 16(7):5928-37. PMC: 6264690. DOI: 10.3390/molecules16075928. View

NAGHSKI J, KREWSON C, Porter W, COUCH J . Factors affecting the rutin contents of dried buckwheat meals. J Am Pharm Assoc Am Pharm Assoc. 1950; 39(12):696-8. DOI: 10.1002/jps.3030391215. View

10.

Ikeda K . Buckwheat: composition, chemistry, and processing. Adv Food Nutr Res. 2002; 44:395-434. DOI: 10.1016/s1043-4526(02)44008-9. View

11.

Vogrincic M, Timoracka M, Melichacova S, Vollmannova A, Kreft I . Degradation of rutin and polyphenols during the preparation of tartary buckwheat bread. J Agric Food Chem. 2010; 58(8):4883-7. DOI: 10.1021/jf9045733. View

12.

Wang M, Liu J, Gao J, Parry J, Wei Y . Antioxidant activity of Tartary buckwheat bran extract and its effect on the lipid profile of hyperlipidemic rats. J Agric Food Chem. 2009; 57(11):5106-12. DOI: 10.1021/jf900194s. View

13.

Yang N, Ren G . Determination of D-chiro-Inositol in tartary buckwheat using high-performance liquid chromatography with an evaporative light-scattering detector. J Agric Food Chem. 2008; 56(3):757-60. DOI: 10.1021/jf0717541. View

14.

He J, Klag M, Whelton P, Mo J, Chen J, Qian M . Oats and buckwheat intakes and cardiovascular disease risk factors in an ethnic minority of China. Am J Clin Nutr. 1995; 61(2):366-72. DOI: 10.1093/ajcn/61.2.366. View

15.

Kalinova J, Vrchotova N . Level of catechin, myricetin, quercetin and isoquercitrin in buckwheat (Fagopyrum esculentum Moench), changes of their levels during vegetation and their effect on the growth of selected weeds. J Agric Food Chem. 2009; 57(7):2719-25. DOI: 10.1021/jf803633f. View

16.

Min B, Lee S, Yoo S, Inglett G, Lee S . Functional characterization of steam jet-cooked buckwheat flour as a fat replacer in cake-baking. J Sci Food Agric. 2010; 90(13):2208-13. DOI: 10.1002/jsfa.4072. View

17.

Guo X, Zhu K, Zhang H, Yao H . Anti-tumor activity of a novel protein obtained from tartary buckwheat. Int J Mol Sci. 2011; 11(12):5201-11. PMC: 3100852. DOI: 10.3390/ijms11125201. View

18.

Dadakova E, Kalinova J . Determination of quercetin glycosides and free quercetin in buckwheat by capillary micellar electrokinetic chromatography. J Sep Sci. 2010; 33(11):1633-8. DOI: 10.1002/jssc.200900809. View

19.

Zou T, Wang M, Gan R, Ling W . Optimization of ultrasound-assisted extraction of anthocyanins from mulberry, using response surface methodology. Int J Mol Sci. 2011; 12(5):3006-17. PMC: 3116171. DOI: 10.3390/ijms12053006. View

20.

Kim D, Hwang I, Lim S, Yoo K, Li H, Kim Y . Germinated Buckwheat extract decreases blood pressure and nitrotyrosine immunoreactivity in aortic endothelial cells in spontaneously hypertensive rats. Phytother Res. 2009; 23(7):993-8. DOI: 10.1002/ptr.2739. View