Novel MIPs-Parabens Based SPE Stationary Phases Characterization and Application

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2019 Sep 22

PMID 31540217

Citations 1

Authors

Angela Tartaglia

Abuzar Kabir

Songul Ulusoy

Halil Ibrahim Ulusoy

Giuseppe Maria Merone

Fabio Savini

Cristian DOvidio

Ugo de Grazia

Serena Gabrielli

Fabio Maroni

Pantaleone Bruni

Fausto Croce

Dora Melucci

Kenneth G Furton

Marcello Locatelli

Affiliations

Soon will be listed here.

Abstract

In this work, the synthesis, characterization, and application of novel parabens imprinted polymers as highly selective solid-phase extraction (SPE) sorbents have been reported. The imprinted polymers were created using sol-gel molecular imprinting process. All the seven parabens were considered herein in order to check the phase selectivity. By means of a validated HPLC-photodiode array detector (PDA) method all seven parabens were resolved in a single chromatographic run of 25 min. These SPE sorbents, packed in SPE empty cartridges, were first characterized in terms of extraction capability, breakthrough volume, retention volume, hold-up volume, number of theoretical plates, and retention factor. Finally, the device was applied to a real urine sample to check the method feasibility on a very complex matrix. The new paraben imprinted SPE sorbents, not yet present in the literature, potentially encourage the development of novel molecularly imprinted polymers (MIPs) to enhance the extraction efficiency, and consequently the overall analytical performances, when the trace quantification is required.

Citing Articles

Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk.

Pajewska-Szmyt M, Biniewska E, Buszewski B, Gadzala-Kopciuch R Materials (Basel). 2020; 13(19).

PMID: 33003301 PMC: 7579064. DOI: 10.3390/ma13194328.

References

Gonzalez-Marino I, Quintana J, Rodriguez I, Cela R . Simultaneous determination of parabens, triclosan and triclocarban in water by liquid chromatography/electrospray ionisation tandem mass spectrometry. Rapid Commun Mass Spectrom. 2009; 23(12):1756-66. DOI: 10.1002/rcm.4069. View

Tartaglia A, Locatelli M, Kabir A, Furton K, Macerola D, Sperandio E . Comparison between Exhaustive and Equilibrium Extraction Using Different SPE Sorbents and Sol-Gel Carbowax 20M Coated FPSE Media. Molecules. 2019; 24(3). PMC: 6385024. DOI: 10.3390/molecules24030382. View

Kabir A, Furton K, Tinari N, Grossi L, Innosa D, Macerola D . Fabric phase sorptive extraction-high performance liquid chromatography-photo diode array detection method for simultaneous monitoring of three inflammatory bowel disease treatment drugs in whole blood, plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2018; 1084:53-63. DOI: 10.1016/j.jchromb.2018.03.028. View

Regueiro J, Becerril E, Garcia-Jares C, Llompart M . Trace analysis of parabens, triclosan and related chlorophenols in water by headspace solid-phase microextraction with in situ derivatization and gas chromatography-tandem mass spectrometry. J Chromatogr A. 2009; 1216(23):4693-702. DOI: 10.1016/j.chroma.2009.04.025. View

Campestre C, Locatelli M, Guglielmi P, De Luca E, Bellagamba G, Menta S . Analysis of imidazoles and triazoles in biological samples after MicroExtraction by packed sorbent. J Enzyme Inhib Med Chem. 2017; 32(1):1-11. PMC: 6010084. DOI: 10.1080/14756366.2017.1354858. View

Ye X, Kuklenyik Z, Bishop A, Needham L, Calafat A . Quantification of the urinary concentrations of parabens in humans by on-line solid phase extraction-high performance liquid chromatography-isotope dilution tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2006; 844(1):53-9. DOI: 10.1016/j.jchromb.2006.06.037. View

Locatelli M, Furton K, Tartaglia A, Sperandio E, Ulusoy H, Kabir A . An FPSE-HPLC-PDA method for rapid determination of solar UV filters in human whole blood, plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2019; 1118-1119:40-50. DOI: 10.1016/j.jchromb.2019.04.028. View

Zotou A, Sakla I, Tzanavaras P . LC-determination of five paraben preservatives in saliva and toothpaste samples using UV detection and a short monolithic column. J Pharm Biomed Anal. 2010; 53(3):785-9. DOI: 10.1016/j.jpba.2010.05.018. View

Locatelli M, Cifelli R, Di Legge C, Barbacane R, Costa N, Fresta M . Simultaneous determination of eperisone hydrochloride and paracetamol in mouse plasma by high performance liquid chromatography-photodiode array detector. J Chromatogr A. 2015; 1388:79-86. DOI: 10.1016/j.chroma.2015.02.008. View

10.

Locatelli M, Ciavarella M, Paolino D, Celia C, Fiscarelli E, Ricciotti G . Determination of ciprofloxacin and levofloxacin in human sputum collected from cystic fibrosis patients using microextraction by packed sorbent-high performance liquid chromatography photodiode array detector. J Chromatogr A. 2015; 1419:58-66. DOI: 10.1016/j.chroma.2015.09.075. View

11.

Chen L, Xu S, Li J . Recent advances in molecular imprinting technology: current status, challenges and highlighted applications. Chem Soc Rev. 2011; 40(5):2922-42. DOI: 10.1039/c0cs00084a. View

12.

Lofgreen J, Ozin G . Controlling morphology and porosity to improve performance of molecularly imprinted sol-gel silica. Chem Soc Rev. 2013; 43(3):911-33. DOI: 10.1039/c3cs60276a. View

13.

DAngelo V, Tessari F, Bellagamba G, De Luca E, Cifelli R, Celia C . Microextraction by packed sorbent and HPLC-PDA quantification of multiple anti-inflammatory drugs and fluoroquinolones in human plasma and urine. J Enzyme Inhib Med Chem. 2016; 31(sup3):110-116. DOI: 10.1080/14756366.2016.1209496. View

14.

Malatesta L, Cosco D, Paolino D, Cilurzo F, Costa N, Di Tullio A . Simultaneous quantification of Gemcitabine and Irinotecan hydrochloride in rat plasma by using high performance liquid chromatography-diode array detector. J Pharm Biomed Anal. 2018; 159:192-199. DOI: 10.1016/j.jpba.2018.06.060. View

15.

Ocana-Gonzalez J, Villar-Navarro M, Ramos-Payan M, Fernandez-Torres R, Bello-Lopez M . New developments in the extraction and determination of parabens in cosmetics and environmental samples. A review. Anal Chim Acta. 2015; 858:1-15. DOI: 10.1016/j.aca.2014.07.002. View

16.

Locatelli M, Ferrone V, Cifelli R, Barbacane R, Carlucci G . Microextraction by packed sorbent and high performance liquid chromatography determination of seven non-steroidal anti-inflammatory drugs in human plasma and urine. J Chromatogr A. 2014; 1367:1-8. DOI: 10.1016/j.chroma.2014.09.034. View

17.

Bielicka-Daszkiewicz K, Voelkel A . Theoretical and experimental methods of determination of the breakthrough volume of SPE sorbents. Talanta. 2009; 80(2):614-21. DOI: 10.1016/j.talanta.2009.07.037. View

18.

Blanco E, Casais M, Mejuto M, Cela R . Combination of off-line solid-phase extraction and on-column sample stacking for sensitive determination of parabens and p-hydroxybenzoic acid in waters by non-aqueous capillary electrophoresis. Anal Chim Acta. 2009; 647(1):104-11. DOI: 10.1016/j.aca.2009.05.024. View

19.

Locatelli M, Tinari N, Grassadonia A, Tartaglia A, Macerola D, Piccolantonio S . FPSE-HPLC-DAD method for the quantification of anticancer drugs in human whole blood, plasma, and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2018; 1095:204-213. DOI: 10.1016/j.jchromb.2018.07.042. View

20.

Locatelli M, Kabir A, Innosa D, Lopatriello T, Furton K . A fabric phase sorptive extraction-High performance liquid chromatography-Photo diode array detection method for the determination of twelve azole antimicrobial drug residues in human plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2016; 1040:192-198. DOI: 10.1016/j.jchromb.2016.10.045. View