» Articles » PMID: 31535650

Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-activated Receptor (PPAR) Activation: a New Potential Multi-target Therapeutic Strategy for the Treatment of Alzheimer's Disease

Overview
Date 2019 Sep 20
PMID 31535650
Citations 9
Authors
Affiliations
Soon will be listed here.
Citing Articles

Role of copper chelating agents: between old applications and new perspectives in neuroscience.

Leuci R, Brunetti L, Tufarelli V, Cerini M, Paparella M, Puvaca N Neural Regen Res. 2024; 20(3):751-762.

PMID: 38886940 PMC: 11433910. DOI: 10.4103/NRR.NRR-D-24-00140.


Historic recurrences in medicinal chemistry: nature-inspired structures as a new opportunity for novel multi-target anti-Alzheimer's drugs.

Piemontese L Neural Regen Res. 2023; 18(12):2671-2672.

PMID: 37449616 PMC: 10358667. DOI: 10.4103/1673-5374.373685.


Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer's Disease.

Carocci A, Barbarossa A, Leuci R, Carrieri A, Brunetti L, Laghezza A Antioxidants (Basel). 2022; 11(9).

PMID: 36139705 PMC: 9495854. DOI: 10.3390/antiox11091631.


Can foods influence the onset and progress of neurodegenerative diseases?.

Piemontese L, Brunetti L, Leuci R Neural Regen Res. 2022; 17(11):2443-2444.

PMID: 35535892 PMC: 9120676. DOI: 10.4103/1673-5374.335810.


A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE).

Leuci R, Brunetti L, Laghezza A, Piemontese L, Carrieri A, Pisani L Molecules. 2022; 27(3).

PMID: 35164223 PMC: 8839882. DOI: 10.3390/molecules27030958.


References
1.
Basavarajappa B, Shivakumar M, Joshi V, Subbanna S . Endocannabinoid system in neurodegenerative disorders. J Neurochem. 2017; 142(5):624-648. PMC: 5669051. DOI: 10.1111/jnc.14098. View

2.
Piemontese L, Vitucci G, Catto M, Laghezza A, Perna F, Rullo M . Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer's Disease. Molecules. 2018; 23(9). PMC: 6225478. DOI: 10.3390/molecules23092182. View

3.
Piemontese L, Fracchiolla G, Carrieri A, Parente M, Laghezza A, Carbonara G . Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175. Eur J Med Chem. 2014; 90:583-94. DOI: 10.1016/j.ejmech.2014.11.044. View

4.
Meinig J, Ferrara S, Banerji T, Banerji T, Sanford-Crane H, Bourdette D . Targeting Fatty-Acid Amide Hydrolase with Prodrugs for CNS-Selective Therapy. ACS Chem Neurosci. 2017; 8(11):2468-2476. PMC: 6342467. DOI: 10.1021/acschemneuro.7b00239. View

5.
Hiremathad A, Piemontese L . Heterocyclic compounds as key structures for the interaction with old and new targets in Alzheimer's disease therapy. Neural Regen Res. 2017; 12(8):1256-1261. PMC: 5607816. DOI: 10.4103/1673-5374.213541. View