Dihydroartemisinin Promotes the Osteogenesis of Human Mesenchymal Stem Cells Via the ERK and Wnt/-Catenin Signaling Pathways

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2019 Sep 20

PMID 31534957

Citations 10

Authors

Licheng Ni

Zhihui Kuang

Zhe Gong

Deting Xue

Qiang Zheng

Affiliations

Soon will be listed here.

Abstract

Dihydroartemisinin (DHA), which is considered to be one of the active compounds within Artemisia annua, has extensively been used in recent years as the most effective drug against malaria, having many biological functions including anticancer, antifungal, and immunomodulatory activities. However, DHA plays a role in the regulation of the proliferation and human mesenchymal stem cells (hMSCs) osteogenic differentiation that remains unknown. We explored DHA's effect on hMSCs' proliferation as well as the osteogenic differentiation, together with its underlying mechanisms of action. We showed that DHA enhanced osteogenic differentiation but had no significant effect on hMSCs' proliferation. It probably exerted its functions through the signaling pathways of ERK1/2 as well as Wnt/. Because DHA has low toxicity and costs, it might be regarded as an important drug for fracture treatment and tissue engineering.

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