Modeling Hematopoietic Disorders in Zebrafish

Overview

Journal Dis Model Mech

Specialty General Medicine

Date 2019 Sep 15

PMID 31519693

Citations 16

Authors

Martina Konantz

Christoph Schurch

Pauline Hanns

Joelle S Muller

Loic Sauteur

Claudia Lengerke

Affiliations

Soon will be listed here.

Abstract

Zebrafish offer a powerful vertebrate model for studies of development and disease. The major advantages of this model include the possibilities of conducting reverse and forward genetic screens and of observing cellular processes by imaging of single cells. Moreover, pathways regulating blood development are highly conserved between zebrafish and mammals, and several discoveries made in fish were later translated to murine and human models. This review and accompanying poster provide an overview of zebrafish hematopoiesis and discuss the existing zebrafish models of blood disorders, such as myeloid and lymphoid malignancies, bone marrow failure syndromes and immunodeficiencies, with a focus on how these models were generated and how they can be applied for translational research.

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