Glycyrrhizic Acid Derivatives As Dengue Virus Inhibitors

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2019 Sep 15

PMID 31519375

Citations 22

Authors

Lidia A Baltina

Yan-Ting Tasi

Su-Hua Huang

Hsueh-Chou Lai

Lia A Baltina

Svetlana F Petrova

Marat S Yunusov

Cheng-Wen Lin

Affiliations

Soon will be listed here.

Abstract

Dengue virus (DENV) is one of the most geographically distributed pathogenic flaviviruses transmitted by mosquitoes Aedes sps. In this study, the structure-antiviral activity relationships of Glycyrrhizic acid (GL) derivatives was evaluated by the inhibitory assays on the cytopathic effect (CPE) and viral infectivity of DENV type 2 (DENV2) in Vero E6 cells. GL (96% purity) had a low cytotoxicity to Vero E6 cells, inhibited DENV2-induced CPE, and reduced the DENV-2 infectivity with the IC50 of 8.1 μM. Conjugation of GL with amino acids or their methyl esters and the introduction of aromatic acylhydrazide residues into the carbohydrate part strongly influenced on the antiviral activity. Among compounds tested GL conjugates with isoleucine 13 and 11-aminoundecanoic acid 17 were found as potent anti-DENV2 inhibitors (IC50 1.2-1.3 μM). Therefore, modification of GL is a perspective way in the search of new antivirals against DENV2 infection.

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