Circulating MicroRNA Trafficking and Regulation: Computational Principles and Practice

Overview

Journal Brief Bioinform

Publisher Oxford University Press

Specialty Biology

Date 2019 Sep 11

PMID 31504144

Citations 4

Authors

Juan Cui

Jiang Shu

Affiliations

Soon will be listed here.

Abstract

Rapid advances in genomics discovery tools and a growing realization of microRNA's implication in intercellular communication have led to a proliferation of studies of circulating microRNA sorting and regulation across cells and different species. Although sometimes, reaching controversial scientific discoveries and conclusions, these studies have yielded new insights in the functional roles of circulating microRNA and a plethora of analytical methods and tools. Here, we consider this body of work in light of key computational principles underpinning discovery of circulating microRNAs in terms of their sorting and targeting, with the goal of providing practical guidance for applications that is focused on the design and analysis of circulating microRNAs and their context-dependent regulation. We survey a broad range of informatics methods and tools that are available to the researcher, discuss their key features, applications and various unsolved problems and close this review with prospects and broader implication of this field.

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