The LUFS Domain, Its Transcriptional Regulator Proteins, and Drug Resistance in the Fungal Pathogen Candida Auris

Overview

Journal Protein Sci

Specialty Biochemistry

Date 2019 Sep 11

PMID 31503375

Citations 6

Authors

Elizabeth Misas

Patricia Escandon

Juan G McEwen

Oliver K Clay

Affiliations

Soon will be listed here.

Abstract

The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., Protein Sci., 2019, 28:788-793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, Candida auris.

Citing Articles

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Candida auris: a global pathogen that has taken root in Colombia.

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