TRPM8-androgen Receptor Association Within Lipid Rafts Promotes Prostate Cancer Cell Migration

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2019 Sep 11

PMID 31501416

Citations 31

Authors

Guillaume P Grolez

Dmitri V Gordiendko

Manon Clarisse

Mehdi Hammadi

Emilie Desruelles

Gaelle Fromont

Natalia Prevarskaya

Christian Slomianny

Dimitra Gkika

Affiliations

Soon will be listed here.

Abstract

In prostate carcinogenesis, androgens are known to control the expression of the transient receptor potential melastatin 8 (TRPM8) protein via activation of androgen receptor (AR). Overexpression and/or activity of TRPM8 channel was shown to suppress prostate cancer (PCa) cell migration. Here we report that at certain concentrations androgens facilitate PCa cell migration. We show that underlying mechanism is inhibition of TRPM8 by activated AR which interacts with the channel within lipid rafts microdomains of the plasma membrane. Thus, our study has identified an additional nongenomic mechanism of the TRPM8 channel regulation by androgens that should be taken into account upon the development of novel therapeutic strategies.

Citing Articles

TRPM channels in human cancers: regulatory mechanism and therapeutic prospects.

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Residues of TRPM8 at the Lipid-Water-Interface have Coevolved with Cholesterol Interaction and are Relevant for Diverse Health Disorders.

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Roles of TRPM channels in glioma.

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Prostate Cancer and the Mevalonate Pathway.

Guerrero-Ochoa P, Rodriguez-Zapater S, Anel A, Esteban L, Camon-Fernandez A, Espilez-Ortiz R Int J Mol Sci. 2024; 25(4).

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