A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases

Overview

Journal J Integr Bioinform

Specialty Biology

Date 2019 Sep 9

PMID 31494632

Citations 21

Authors

Olga Zolotareva

Maren Kleine

Affiliations

Soon will be listed here.

Abstract

Modern high-throughput experiments provide us with numerous potential associations between genes and diseases. Experimental validation of all the discovered associations, let alone all the possible interactions between them, is time-consuming and expensive. To facilitate the discovery of causative genes, various approaches for prioritization of genes according to their relevance for a given disease have been developed. In this article, we explain the gene prioritization problem and provide an overview of computational tools for gene prioritization. Among about a hundred of published gene prioritization tools, we select and briefly describe 14 most up-to-date and user-friendly. Also, we discuss the advantages and disadvantages of existing tools, challenges of their validation, and the directions for future research.

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