Emerging Trends in Paper Spray Mass Spectrometry: Microsampling, Storage, Direct Analysis, and Applications

Overview

Journal Mass Spectrom Rev

Publisher Wiley

Specialty Chemistry

Date 2019 Sep 7

PMID 31491055

Citations 24

Authors

Benjamin S Frey

Deidre E Damon

Abraham K Badu-Tawiah

Affiliations

Soon will be listed here.

Abstract

Recent advancements in the sensitivity of chemical instrumentation have led to increased interest in the use of microsamples for translational and biomedical research. Paper substrates are by far the most widely used media for biofluid collection, and mass spectrometry is the preferred method of analysis of the resultant dried blood spot (DBS) samples. Although there have been a variety of review papers published on DBS, there has been no attempt to unify the century old DBS methodology with modern applications utilizing modified paper and paper-based microfluidics for sampling, storage, processing, and analysis. This critical review will discuss how mass spectrometry has expanded the utility of paper substrates from sample collection and storage, to direct complex mixture analysis to on-surface reaction monitoring.

Citing Articles

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