Interleukin 17 Receptor E (IL-17RE) and IL-17C Mediate the Recruitment of Neutrophils During Acute Pneumonia

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2019 Sep 5

PMID 31481409

Citations 13

Authors

Patrick Steck

Felix Ritzmann

Anja Honecker

Giovanna Vella

Christian Herr

Rosmarie Gaupp

Markus Bischoff

Timotheus Speer

Thomas Tschernig

Robert Bals

Christoph Beisswenger

Affiliations

Soon will be listed here.

Abstract

Neutrophils contribute to lung injury in acute pneumococcal pneumonia. The interleukin 17 receptor E (IL-17RE) is the functional receptor for the epithelial-derived cytokine IL-17C, which is known to mediate innate immune functions. The aim of this study was to investigate the contribution of IL-17RE/IL-17C to pulmonary inflammation in a mouse model of acute pneumonia. Numbers of neutrophils and the expression levels of the cytokine granulocyte colony-stimulating factor (G-CSF) and tumor necrosis factor alpha (TNF-α) were decreased in lungs of IL-17RE-deﬁcient ( ) mice infected with Numbers of alveolar macrophages rapidly declined in both wild-type (WT) and mice and recovered 72 h after infection. There were no clear differences in the elimination of bacteria and numbers of blood granulocytes between infected WT and mice. The fractions of granulocyte-monocyte progenitors (GMPs) were significantly reduced in infected mice. Numbers of neutrophils were significantly reduced in lungs of mice deficient for IL-17C 24 h after infection with These data indicate that the IL-17C/IL-17RE axis promotes the recruitment of neutrophils without affecting the recovery of alveolar macrophages in the acute phase of lung infection.

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