IL-17C and IL-17RE Promote Wound Closure in a -Based Murine Wound Infection Model

Overview

Journal Microorganisms

Specialty Microbiology

Date 2021 Sep 28

PMID 34576717

Citations 6

Authors

Linda Patzold

Alexandra Stark

Felix Ritzmann

Carola Meier

Thomas Tschernig

Jorg Reichrath

Robert Bals

Markus Bischoff

Christoph Beisswenger

Affiliations

Soon will be listed here.

Abstract

The epithelial cytokine interleukin-17C (IL-17C) mediates inflammation through the interleukin 17 receptor E (IL-17RE). Prior studies showed a detrimental role of IL-17C in the pathogenesis of immune-mediated skin diseases (e.g., psoriasis). Here, we examined the role of IL-17C/IL-17RE in wound closure in a wound infection model. We demonstrate that wound closure is significantly delayed in IL-17RE ()- and 17C ()-deficient mice. There was no significant difference between WT, , and mice in the absence of infection. Deficiency for IL-17RE and IL-17C did not significantly affect the elimination of bacteria. IL-17C expression was increased in the epidermis of human -infected skin. Our results indicate that the IL-17C/IL-17RE axis contributes to the closure of infected wounds but does not contribute to the elimination of .

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